TY - JOUR
T1 - Fatty acid metabolism in the progression and resolution of CNS disorders
AU - Bogie, Jeroen F.J.
AU - Haidar, Mansour
AU - Kooij, Gijs
AU - Hendriks, Jerome J.A.
PY - 2020/1
Y1 - 2020/1
N2 - Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid metabolism and the fatty acid lipidome in health and disease. A growing body of evidence indicates that imbalances in the metabolism and level of fatty acids drive the initiation and progression of central nervous system (CNS) disorders such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. Here, we provide an in-depth overview on the impact of the β-oxidation, synthesis, desaturation, elongation, and peroxidation of fatty acids on the pathophysiology of these and other neurological disorders. Furthermore, we discuss the impact of individual fatty acids species, acquired through the diet or endogenously synthesized in mammals, on neuroinflammation, neurodegeneration, and CNS repair. The findings discussed in this review highlight the therapeutic potential of modulators of fatty acid metabolism and the fatty acid lipidome in CNS disorders, and underscore the diagnostic value of lipidome signatures in these diseases.
AB - Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid metabolism and the fatty acid lipidome in health and disease. A growing body of evidence indicates that imbalances in the metabolism and level of fatty acids drive the initiation and progression of central nervous system (CNS) disorders such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. Here, we provide an in-depth overview on the impact of the β-oxidation, synthesis, desaturation, elongation, and peroxidation of fatty acids on the pathophysiology of these and other neurological disorders. Furthermore, we discuss the impact of individual fatty acids species, acquired through the diet or endogenously synthesized in mammals, on neuroinflammation, neurodegeneration, and CNS repair. The findings discussed in this review highlight the therapeutic potential of modulators of fatty acid metabolism and the fatty acid lipidome in CNS disorders, and underscore the diagnostic value of lipidome signatures in these diseases.
KW - Central nervous system
KW - Immunometabolism
KW - Lipids
KW - Neurodegeneration
KW - Neuroinflammation
KW - Remyelination
UR - http://www.scopus.com/inward/record.url?scp=85078810377&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.addr.2020.01.004
DO - https://doi.org/10.1016/j.addr.2020.01.004
M3 - Review article
C2 - 31987838
SN - 0169-409X
VL - 159
SP - 198
EP - 213
JO - Advanced drug delivery reviews
JF - Advanced drug delivery reviews
ER -