TY - JOUR
T1 - FDG-PET in the detection of early pancreatic cancer in a BOP hamster model
AU - van Kouwen, Mariëtte C. A.
AU - Laverman, Peter
AU - van Krieken, J. Han
AU - Oyen, Wim J. G.
AU - Jansen, Jan B. M. J.
AU - Drenth, Joost P. H.
PY - 2005/7
Y1 - 2005/7
N2 - Background: The prognosis of pancreatic cancer (PC) is highly dependent on the stage of the disease, and early recognition improves survival. Positron emission tomography (PET) using 18F-fluoro-2-deoxyglucose ([ 18F]FDG) has been established as an important clinical tool for PC diagnosis, but it is not known whether FDG-PET detects premalignant stages of PC. We speculate that [18F]FDG uptake precedes the onset of PC in a hamster model. We used the N-nitrosobis(2-oxopropyl)amine (BOP) model, as these animals consistently develop PC within 20 weeks after first injection. Methods: Male Syrian hamsters were injected once a week with 10 mg BOP/kg body weight for 10 consecutive weeks. Terminal autopsy took place in groups of five hamsters from 4 weeks until 28 weeks after first BOP injection. After an 8-h fast, hamsters were injected with [18F]FDG and sacrificed 1 h after [ 18F]FDG injection. The pancreata were histopathologically examined, and the [18F]FDG uptake was determined and expressed as percentage of the injected dose per gram tissue (%ID/g). Results: Seven of 55 hamsters developed macroscopic signs of tumor. Histopathological examination revealed PC in 13 hamsters. [18F]FDG uptake increased gradually with time and was significantly higher in the group with PC compared to the group without PC. Conclusion: [18F]FDG accumulates preferentially in PC, and pancreata exposed to BOP showed a gradual increase in [18F]FDG accumulation. © 2005 Elsevier Inc. All rights reserved.
AB - Background: The prognosis of pancreatic cancer (PC) is highly dependent on the stage of the disease, and early recognition improves survival. Positron emission tomography (PET) using 18F-fluoro-2-deoxyglucose ([ 18F]FDG) has been established as an important clinical tool for PC diagnosis, but it is not known whether FDG-PET detects premalignant stages of PC. We speculate that [18F]FDG uptake precedes the onset of PC in a hamster model. We used the N-nitrosobis(2-oxopropyl)amine (BOP) model, as these animals consistently develop PC within 20 weeks after first injection. Methods: Male Syrian hamsters were injected once a week with 10 mg BOP/kg body weight for 10 consecutive weeks. Terminal autopsy took place in groups of five hamsters from 4 weeks until 28 weeks after first BOP injection. After an 8-h fast, hamsters were injected with [18F]FDG and sacrificed 1 h after [ 18F]FDG injection. The pancreata were histopathologically examined, and the [18F]FDG uptake was determined and expressed as percentage of the injected dose per gram tissue (%ID/g). Results: Seven of 55 hamsters developed macroscopic signs of tumor. Histopathological examination revealed PC in 13 hamsters. [18F]FDG uptake increased gradually with time and was significantly higher in the group with PC compared to the group without PC. Conclusion: [18F]FDG accumulates preferentially in PC, and pancreata exposed to BOP showed a gradual increase in [18F]FDG accumulation. © 2005 Elsevier Inc. All rights reserved.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=20744447080&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/15982574
U2 - https://doi.org/10.1016/j.nucmedbio.2005.03.002
DO - https://doi.org/10.1016/j.nucmedbio.2005.03.002
M3 - Article
C2 - 15982574
SN - 0969-8051
VL - 32
SP - 445
EP - 450
JO - Nuclear medicine and biology
JF - Nuclear medicine and biology
IS - 5
ER -