TY - JOUR
T1 - Feasibility of arterial spin labeling on a 1T open MRI scanner
AU - Heijtel, Dennis F. R.
AU - van Osch, Matthias J. P.
AU - Caan, Matthan W. A.
AU - Majoie, Charles B.
AU - VanBavel, Ed
AU - Nederveen, Aart J.
PY - 2013
Y1 - 2013
N2 - To determine the clinical feasibility of arterial spin labeling (ASL) on a 1T open bore scanner. First, the optimal postlabeling delay (PLD) at 1T was determined (n = 5), with and without vascular crushing. Second, the effect of different labeling approaches (pseudo-continuous ASL [pCASL] vs. pulsed ASL [PASL]), background suppression (BSup) and readout options (GRASE vs. EPI) was investigated (n = 9). Each effect was quantified by calculating the signal-to-noise ratio (SNR), convergence, and number of significant gray matter (GM) voxels in the ASL images. Finally, an example of an obese volunteer who could not have been scanned in a cylindrical scanner is presented. The optimal PLDs were found to be 1300 msec for pCASL with and without vascular crushing. pCASL labeling outperformed PASL labeling in terms of convergence, anatomical correspondence between GM and perfusion maps, and SNR (P < 0.05). BSup appeared to have no additional value on the convergence, anatomical GM correspondence, and SNR (P > 0.05). EPI readout yielded a slightly better convergence, while the SNR of the GRASE readout was higher (P < 0.05). ASL on 1T is clinically feasible using state-of-the-art sequences that were primarily developed for higher field strengths
AB - To determine the clinical feasibility of arterial spin labeling (ASL) on a 1T open bore scanner. First, the optimal postlabeling delay (PLD) at 1T was determined (n = 5), with and without vascular crushing. Second, the effect of different labeling approaches (pseudo-continuous ASL [pCASL] vs. pulsed ASL [PASL]), background suppression (BSup) and readout options (GRASE vs. EPI) was investigated (n = 9). Each effect was quantified by calculating the signal-to-noise ratio (SNR), convergence, and number of significant gray matter (GM) voxels in the ASL images. Finally, an example of an obese volunteer who could not have been scanned in a cylindrical scanner is presented. The optimal PLDs were found to be 1300 msec for pCASL with and without vascular crushing. pCASL labeling outperformed PASL labeling in terms of convergence, anatomical correspondence between GM and perfusion maps, and SNR (P < 0.05). BSup appeared to have no additional value on the convergence, anatomical GM correspondence, and SNR (P > 0.05). EPI readout yielded a slightly better convergence, while the SNR of the GRASE readout was higher (P < 0.05). ASL on 1T is clinically feasible using state-of-the-art sequences that were primarily developed for higher field strengths
U2 - https://doi.org/10.1002/jmri.23880
DO - https://doi.org/10.1002/jmri.23880
M3 - Article
C2 - 23097383
SN - 1053-1807
VL - 37
SP - 958
EP - 964
JO - Journal of magnetic resonance imaging
JF - Journal of magnetic resonance imaging
IS - 4
ER -