TY - JOUR
T1 - Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis
T2 - A pilot study
AU - Prouskas, Stefanos E.
AU - Chiaravalloti, Nancy D.
AU - Kant, Neeltje
AU - Ball, Karlene K.
AU - de Groot, Vincent
AU - Uitdehaag, Bernard M. J.
AU - Geurts, Jeroen J. G.
AU - Kooij, Elizabeth A.
AU - Hulst, Hanneke E.
N1 - Funding Information: We are thankful to Johan Koops and John Mens for his assistance with patient screening and inclusion, and Elisa Maes for testing the study protocol in a two-patient pilot. We are also grateful to Larissa Meijer, Maaike Ouwerkerk, Elisabeth van Goolen, Lonny Mulder, Leone Eichelberg, and Renske Standhardt who conducted the compensatory strategies training. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Dutch MS Research Foundation (grant number 14?881) and the MoveS Foundation (grant number 16?954 A/B). Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Dutch MS Research Foundation (grant number 14–881) and the MoveS Foundation (grant number 16–954 A/B). Publisher Copyright: © The Author(s), 2021.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Background: The feasibility of cognitive rehabilitation is rarely investigated in patients with advanced multiple sclerosis. Methods: Eighteen patients with advanced multiple sclerosis (median EDSS = 7.5) were randomized into restorative or compensatory cognitive rehabilitation. Feasibility was determined by adherence rate, completion rate, patient satisfaction, self-reported fatigue, training difficulty, and training duration. Results: Adherence rates and completion rates were over 70%, and patients were highly satisfied in both groups. Energy levels decreased minimally during the sessions (pre = 6.9 vs post = 6.4). Training difficulty (4.6) and duration (5.7) were close to ideal (scale 1–10, 5 = ideal). Conclusions: Cognitive rehabilitation, with minor adjustments, appears feasible in patients with advanced multiple sclerosis.
AB - Background: The feasibility of cognitive rehabilitation is rarely investigated in patients with advanced multiple sclerosis. Methods: Eighteen patients with advanced multiple sclerosis (median EDSS = 7.5) were randomized into restorative or compensatory cognitive rehabilitation. Feasibility was determined by adherence rate, completion rate, patient satisfaction, self-reported fatigue, training difficulty, and training duration. Results: Adherence rates and completion rates were over 70%, and patients were highly satisfied in both groups. Energy levels decreased minimally during the sessions (pre = 6.9 vs post = 6.4). Training difficulty (4.6) and duration (5.7) were close to ideal (scale 1–10, 5 = ideal). Conclusions: Cognitive rehabilitation, with minor adjustments, appears feasible in patients with advanced multiple sclerosis.
KW - Cognition
KW - feasibility
KW - multiple sclerosis
KW - progressive
KW - rehabilitation
UR - http://www.scopus.com/inward/record.url?scp=85121053752&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/20552173211064473
DO - https://doi.org/10.1177/20552173211064473
M3 - Article
C2 - 34917392
SN - 2055-2173
VL - 7
JO - Multiple Sclerosis Journal - Experimental, Translational and Clinical
JF - Multiple Sclerosis Journal - Experimental, Translational and Clinical
IS - 4
ER -