Feasibility of curative radiotherapy with a concomitant boost technique in 33 patients with non-small cell lung cancer (NSCLC)

A. L. Schuster-Uitterhoeve, M. C. Hulshof, D. Gonzàlez Gonzàlez, M. Koolen, P. Sminia

Research output: Contribution to journalComment/Letter to the editorAcademic

22 Citations (Scopus)


Thirty-three patients with an inoperable NSCLC were treated with a dose of 60 Gy/20 fractions/25 days, using a concomitant boost technique. A dose of 40 Gy/2 Gy/25 days was given to the tumor area and a part (15 patients) or the whole (18 patients) mediastinum. During each session a simultaneous boost to the tumor of 1 Gy was administered. Moderate acute oesophageal toxicity was observed in 7/33 patients (22%). One out of 33 patients developed serious late oesophageal toxicity. A correlation between the oesophageal toxicity, absorbed oesophageal dose of irradiation and length of the elective field was observed. Five out of 33 patients developed subacute radiation pneumonitis grade 2 or 3. In selected patients with inoperable NSCLC radiotherapy, with a dose of 60 Gy/20 fractions/25 days, using a concomitant technique is feasible
Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalRadiotherapy and oncology
Issue number3
Publication statusPublished - Sept 1993


  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung/radiotherapy
  • Esophagus/radiation effects
  • Female
  • Humans
  • Lung Neoplasms/radiotherapy
  • Male
  • Middle Aged
  • Radiation Injuries/pathology
  • Radiation Pneumonitis/pathology
  • Radiotherapy Dosage
  • Radiotherapy, High-Energy/adverse effects

Cite this