TY - JOUR
T1 - Feasibility of PET/CT system performance harmonisation for quantitative multicentre 89Zr studies
AU - on behalf of EARL
AU - Kaalep, Andres
AU - Huisman, Marc
AU - Sera, Terez
AU - Vugts, Danielle
AU - Boellaard, Ronald
PY - 2018
Y1 - 2018
N2 - Purpose: The aim of this study was to investigate the variability in quantitative performance and feasibility of quantitative harmonisation in 89Zr PET/CT imaging. Methods: Eight EANM EARL-accredited (Kaalep A et al., Eur J Nucl Med Mol Imaging 45:412–22, 2018) PET/CT systems were investigated using phantom acquisitions of uniform and NEMA NU2-2007 body phantoms. The phantoms were filled according to EANM EARL guidelines for [18F]FDG, but [18F]FDG solution was replaced by a 89Zr calibration mixture. For each system, standard uptake value (SUV) accuracy and recovery coefficients (RC) using SUVmean, SUVmax and SUVpeak metrics were determined. Results: All eight investigated systems demonstrated similarly shaped RC curves, and five of them exhibited closely aligning recoveries when SUV bias correction was applied. From the evaluated metrics, SUVpeak was found to be least sensitive to noise and reconstruction differences among different systems. Conclusions: Harmonisation of PET/CT scanners for quantitative 89Zr studies is feasible when proper scanner-dose calibrator cross-calibration and harmonised image reconstruction procedures are followed. An accreditation programme for PET/CT scanners would facilitate multicentre 89Zr quantitative studies.
AB - Purpose: The aim of this study was to investigate the variability in quantitative performance and feasibility of quantitative harmonisation in 89Zr PET/CT imaging. Methods: Eight EANM EARL-accredited (Kaalep A et al., Eur J Nucl Med Mol Imaging 45:412–22, 2018) PET/CT systems were investigated using phantom acquisitions of uniform and NEMA NU2-2007 body phantoms. The phantoms were filled according to EANM EARL guidelines for [18F]FDG, but [18F]FDG solution was replaced by a 89Zr calibration mixture. For each system, standard uptake value (SUV) accuracy and recovery coefficients (RC) using SUVmean, SUVmax and SUVpeak metrics were determined. Results: All eight investigated systems demonstrated similarly shaped RC curves, and five of them exhibited closely aligning recoveries when SUV bias correction was applied. From the evaluated metrics, SUVpeak was found to be least sensitive to noise and reconstruction differences among different systems. Conclusions: Harmonisation of PET/CT scanners for quantitative 89Zr studies is feasible when proper scanner-dose calibrator cross-calibration and harmonised image reconstruction procedures are followed. An accreditation programme for PET/CT scanners would facilitate multicentre 89Zr quantitative studies.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057040355&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30460577
U2 - https://doi.org/10.1186/s40658-018-0226-7
DO - https://doi.org/10.1186/s40658-018-0226-7
M3 - Article
C2 - 30460577
SN - 2197-7364
VL - 5
JO - EJNMMI physics
JF - EJNMMI physics
IS - 1
M1 - 26
ER -