Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study: A Longitudinal Multicenter Cohort Study

Nancy Deianova; Sofia El Manouni El Hassani; Hendrik J. Niemarkt; Veerle Cossey; Anton H. van Kaam; Floor Jenken; Mirjam M. van Weissenbruch; Esmee M. Doedes; Kyra Baelde; Renee Menezes; Marc A. Benninga; Wouter J. de Jonge; Nanne K. de Boer; Tim G. de Meij

doi:https://doi.org/10.3390/bios10050050

Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study: A Longitudinal Multicenter Cohort Study

Nancy Deianova, Sofia El Manouni El Hassani, Hendrik J. Niemarkt, Veerle Cossey, Anton H. van Kaam, Floor Jenken, Mirjam M. van Weissenbruch, Esmee M. Doedes, Kyra Baelde, Renee Menezes, Marc A. Benninga, Wouter J. de Jonge, Nanne K. de Boer, Tim G. de Meij

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Fecal volatile organic compounds (VOC) reflect human and gut microbiota metabolic pathways and their interaction. VOC behold potential as non-invasive preclinical diagnostic biomarkers in various diseases, e.g., necrotizing enterocolitis and late onset sepsis. There is a need for standardization and assessment of the influence of clinical and environmental factors on the VOC outcome before this technique can be applied in clinical practice. The aim of this study was to investigate the influence of gestational age (GA) and mode of delivery on the fecal VOC pattern in preterm infants born below 30 weeks of gestation. Longitudinal fecal samples, collected on days 7, 14, and 21 postnatally, were analyzed by an electronic nose device (Cyranose 320®). In total, 58 preterm infants were included (29 infants born at GA 24-26 weeks vs. 29 at 27-29 completed weeks, 24 vaginally born vs. 34 via C-section). No differences were identified at any predefined time point in terms of GA and delivery mode (p > 0.05). We, therefore, concluded that correction for these factors in this population is not warranted when performing fecal VOC analysis in the first three weeks of life.

Original language	English
Article number	bios10050050
Journal	Biosensors
Volume	10
Issue number	5
DOIs	https://doi.org/10.3390/bios10050050
Publication status	Published - 11 May 2020

Keywords

ENose
Electronic nose
Flatography
Gestational age
Metabolomics
Mode of delivery
Preterm infants
VOC
Volatile organic compound

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https://doi.org/10.3390/bios10050050

Cite this

Deianova, N., Hassani, S. E. M. E., Niemarkt, H. J., Cossey, V., Kaam, A. H. V., Jenken, F., Weissenbruch, M. M. V., Doedes, E. M., Baelde, K., Menezes, R., Benninga, M. A., Jonge, W. J. D., Boer, N. K. D., & Meij, T. G. D. (2020). Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study: A Longitudinal Multicenter Cohort Study. Biosensors, 10(5), Article bios10050050. https://doi.org/10.3390/bios10050050

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title = "Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study: A Longitudinal Multicenter Cohort Study",

abstract = "Fecal volatile organic compounds (VOC) reflect human and gut microbiota metabolic pathways and their interaction. VOC behold potential as non-invasive preclinical diagnostic biomarkers in various diseases, e.g., necrotizing enterocolitis and late onset sepsis. There is a need for standardization and assessment of the influence of clinical and environmental factors on the VOC outcome before this technique can be applied in clinical practice. The aim of this study was to investigate the influence of gestational age (GA) and mode of delivery on the fecal VOC pattern in preterm infants born below 30 weeks of gestation. Longitudinal fecal samples, collected on days 7, 14, and 21 postnatally, were analyzed by an electronic nose device (Cyranose 320{\textregistered}). In total, 58 preterm infants were included (29 infants born at GA 24-26 weeks vs. 29 at 27-29 completed weeks, 24 vaginally born vs. 34 via C-section). No differences were identified at any predefined time point in terms of GA and delivery mode (p > 0.05). We, therefore, concluded that correction for these factors in this population is not warranted when performing fecal VOC analysis in the first three weeks of life.",

keywords = "ENose, Electronic nose, Flatography, Gestational age, Metabolomics, Mode of delivery, Preterm infants, VOC, Volatile organic compound",

author = "Nancy Deianova and Hassani, {Sofia El Manouni El} and Niemarkt, {Hendrik J.} and Veerle Cossey and Kaam, {Anton H. van} and Floor Jenken and Weissenbruch, {Mirjam M. van} and Doedes, {Esmee M.} and Kyra Baelde and Renee Menezes and Benninga, {Marc A.} and Jonge, {Wouter J. de} and Boer, {Nanne K. de} and Meij, {Tim G. de}",

note = "Funding Information: Funding: This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement No 814168 and from The Stichting Zeldzame Ziekten Fonds. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = may,

day = "11",

doi = "https://doi.org/10.3390/bios10050050",

language = "English",

volume = "10",

journal = "Biosensors",

issn = "2079-6374",

publisher = "MDPI",

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Deianova, N , Hassani, SEME, Niemarkt, HJ, Cossey, V, Kaam, AHV, Jenken, F, Weissenbruch, MMV, Doedes, EM, Baelde, K, Menezes, R, Benninga, MA, Jonge, WJD, Boer, NKD & Meij, TGD 2020, 'Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study: A Longitudinal Multicenter Cohort Study', Biosensors, vol. 10, no. 5, bios10050050. https://doi.org/10.3390/bios10050050

Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study: A Longitudinal Multicenter Cohort Study. / Deianova, Nancy ; Hassani, Sofia El Manouni El; Niemarkt, Hendrik J. et al.
In: Biosensors, Vol. 10, No. 5, bios10050050, 11.05.2020.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study

T2 - A Longitudinal Multicenter Cohort Study

AU - Deianova, Nancy

AU - Hassani, Sofia El Manouni El

AU - Niemarkt, Hendrik J.

AU - Cossey, Veerle

AU - Kaam, Anton H. van

AU - Jenken, Floor

AU - Weissenbruch, Mirjam M. van

AU - Doedes, Esmee M.

AU - Baelde, Kyra

AU - Menezes, Renee

AU - Benninga, Marc A.

AU - Jonge, Wouter J. de

AU - Boer, Nanne K. de

AU - Meij, Tim G. de

N1 - Funding Information: Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 814168 and from The Stichting Zeldzame Ziekten Fonds. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/5/11

Y1 - 2020/5/11

N2 - Fecal volatile organic compounds (VOC) reflect human and gut microbiota metabolic pathways and their interaction. VOC behold potential as non-invasive preclinical diagnostic biomarkers in various diseases, e.g., necrotizing enterocolitis and late onset sepsis. There is a need for standardization and assessment of the influence of clinical and environmental factors on the VOC outcome before this technique can be applied in clinical practice. The aim of this study was to investigate the influence of gestational age (GA) and mode of delivery on the fecal VOC pattern in preterm infants born below 30 weeks of gestation. Longitudinal fecal samples, collected on days 7, 14, and 21 postnatally, were analyzed by an electronic nose device (Cyranose 320®). In total, 58 preterm infants were included (29 infants born at GA 24-26 weeks vs. 29 at 27-29 completed weeks, 24 vaginally born vs. 34 via C-section). No differences were identified at any predefined time point in terms of GA and delivery mode (p > 0.05). We, therefore, concluded that correction for these factors in this population is not warranted when performing fecal VOC analysis in the first three weeks of life.

AB - Fecal volatile organic compounds (VOC) reflect human and gut microbiota metabolic pathways and their interaction. VOC behold potential as non-invasive preclinical diagnostic biomarkers in various diseases, e.g., necrotizing enterocolitis and late onset sepsis. There is a need for standardization and assessment of the influence of clinical and environmental factors on the VOC outcome before this technique can be applied in clinical practice. The aim of this study was to investigate the influence of gestational age (GA) and mode of delivery on the fecal VOC pattern in preterm infants born below 30 weeks of gestation. Longitudinal fecal samples, collected on days 7, 14, and 21 postnatally, were analyzed by an electronic nose device (Cyranose 320®). In total, 58 preterm infants were included (29 infants born at GA 24-26 weeks vs. 29 at 27-29 completed weeks, 24 vaginally born vs. 34 via C-section). No differences were identified at any predefined time point in terms of GA and delivery mode (p > 0.05). We, therefore, concluded that correction for these factors in this population is not warranted when performing fecal VOC analysis in the first three weeks of life.

KW - ENose

KW - Electronic nose

KW - Flatography

KW - Gestational age

KW - Metabolomics

KW - Mode of delivery

KW - Preterm infants

KW - VOC

KW - Volatile organic compound

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U2 - https://doi.org/10.3390/bios10050050

DO - https://doi.org/10.3390/bios10050050

M3 - Article

C2 - 32403393

SN - 2079-6374

VL - 10

JO - Biosensors

JF - Biosensors

IS - 5

M1 - bios10050050

ER -

Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study: A Longitudinal Multicenter Cohort Study

Abstract

Keywords

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