Fel d 1-specific IgG antibodies induced by natural exposure have blocking activity in skin tests

A. M. Witteman, S. O. Stapel, D. H. Sjamsoedin, H. M. Jansen, R. C. Aalberse, J. S. van der Zee

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Abstract

Cat-allergic patients frequently have IgG antibodies directed against Fel d 1. The aim of this study was to investigate whether these IgG antibodies influence the results of the skin test. Titrated skin tests were performed with Fel d 1 and IgE and IgG antibody levels were measured in 59 patients with cat allergy. Levels of specific IgG against Fel d 1 ranged from less than 0.25 to 3.5 microgram/ml. By means of a multiple regression analysis it was shown that the amount of specific IgG antibodies contributes significantly to the results of the skin test. Presence of specific IgG against Fel d 1 was accompanied by higher skin thresholds for Fel d 1. In conclusion, this study indicates that even low levels of specific IgG, induced by natural exposure to cat allergens, have a blocking effect on the early phase skin reaction
Original languageEnglish
Pages (from-to)369-375
JournalInternational archives of allergy and immunology
Volume109
Issue number4
DOIs
Publication statusPublished - 1996

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