TY - JOUR
T1 - Klinisch beloop van covid-19 in Nederland
AU - Ariës, Marcel J. H.
AU - van den Bergh, Joop P.
AU - Beudel, Martijn
AU - Boersma, Wim
AU - Dormans, Tom
AU - Douma, Renee
AU - Eerens, Annet
AU - Elbers, Paul W. G.
AU - Fleuren, Lucas M.
AU - Gritters van den Oever, Niels C.
AU - de Haan, Lianne
AU - van der Horst, Iwan J. C. C.
AU - Hu, Shi
AU - Hubers, Deborah
AU - Janssen, Marcus L. F.
AU - de Kruif, Martijn
AU - Kubben, Pieter L.
AU - van Kuijk, Sander M. J.
AU - Noordzij, Peter G.
AU - Ottenhoff, Maarten
AU - Piña-Fuentes, Dan A. I.
AU - Potters, Wouter V.
AU - Reidinga, Auke C.
AU - Renckens, Roos S. C.
AU - Rigter, Sander
AU - Rusch, Daisy
AU - Schinkel, Michiel
AU - Sigaloff, Kim C. E.
AU - Simsek, Suat
AU - Stassen, Patricia
AU - Stassen, Robert
AU - Thomas, Rajat M.
AU - van Wingen, Guido A.
AU - Vonk Noordegraaf, Anton
AU - Welling, Max
AU - Wiersinga, W. Joost
AU - Wolvers, Marije D. J.
AU - Wyers, Caroline E.
N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/1/11
Y1 - 2021/1/11
N2 - OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands. DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported. METHODS: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission. RESULTS: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels. CONCLUSION: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.
AB - OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands. DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported. METHODS: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission. RESULTS: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels. CONCLUSION: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.
UR - http://www.scopus.com/inward/record.url?scp=85102602349&partnerID=8YFLogxK
M3 - Article
C2 - 33651497
SN - 0028-2162
VL - 165
JO - Nederlands Tijdschrift voor Geneeskunde
JF - Nederlands Tijdschrift voor Geneeskunde
ER -