TY - JOUR
T1 - Cross-sectional and longitudinal correlations between the Arm Function in Multiple Sclerosis Questionnaire (AMSQ) and other outcome measures in multiple sclerosis
AU - Molenaar, P. C. G.
AU - Strijbis, E. M. M.
AU - van Munster, C. E. P.
AU - Uitdehaag, B. M. J.
AU - Kalkers, N. F.
N1 - Funding Information: None. No funding to declare. Publisher Copyright: © 2022
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Background: The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) is the first validated disease specific patient-reported outcome measure (PROM) designed to assess upper extremity function in patients with multiple sclerosis (MS). Objective: To determine correlations between the AMSQ and established physician- and performance based outcome measures. Methods: In a cross-sectional cohort of 533 patients correlations between the AMSQ and the Expanded Disability Status Scale (EDSS), its functional systems, the 9-Hole Peg Test (9-HPT) and the Timed-25 Foot Walk (T25FW) were determined. Subgroup analyses were performed as well. Also, correlations were determined in 110 of 533 patients with available longitudinal data. Results: Strongest correlations were found in the cross-sectional cohort between the AMSQ and the EDSS (β 0.60, p<.001), the 9-HPT dominant hand (β 0.52, p<.001) and 9-HPT non-dominant hand (β 0.46, p<.001), the Pyramidal (β 0.57 p<.001) and the Cerebellar functional system (β 0.54, p<.001) of the EDSS. Conclusion: The moderate correlations between the AMSQ and several established physician- and performance based outcome measures underline that the AMSQ, an easily at long-distance administrable PROM, could be considered as a reliable outcome measure for the monitoring of MS in daily practice. Additional research is needed to support these findings.
AB - Background: The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) is the first validated disease specific patient-reported outcome measure (PROM) designed to assess upper extremity function in patients with multiple sclerosis (MS). Objective: To determine correlations between the AMSQ and established physician- and performance based outcome measures. Methods: In a cross-sectional cohort of 533 patients correlations between the AMSQ and the Expanded Disability Status Scale (EDSS), its functional systems, the 9-Hole Peg Test (9-HPT) and the Timed-25 Foot Walk (T25FW) were determined. Subgroup analyses were performed as well. Also, correlations were determined in 110 of 533 patients with available longitudinal data. Results: Strongest correlations were found in the cross-sectional cohort between the AMSQ and the EDSS (β 0.60, p<.001), the 9-HPT dominant hand (β 0.52, p<.001) and 9-HPT non-dominant hand (β 0.46, p<.001), the Pyramidal (β 0.57 p<.001) and the Cerebellar functional system (β 0.54, p<.001) of the EDSS. Conclusion: The moderate correlations between the AMSQ and several established physician- and performance based outcome measures underline that the AMSQ, an easily at long-distance administrable PROM, could be considered as a reliable outcome measure for the monitoring of MS in daily practice. Additional research is needed to support these findings.
KW - Arm Function in Multiple Sclerosis Questionnaire (AMSQ)
KW - Multiple sclerosis (MS)
KW - Outcome measures in multiple sclerosis
KW - Patient-reported outcome measure (PROM)
KW - Upper extremity function in multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85128218760&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.msard.2022.103725
DO - https://doi.org/10.1016/j.msard.2022.103725
M3 - Article
C2 - 35421639
SN - 2211-0348
VL - 61
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
M1 - 103725
ER -