TY - JOUR
T1 - First participant diagnosed with Creutzfeldt-Jakob disease in the population-based Rotterdam Study was classified with mild cognitive impairment
AU - Karamujić-Čomić, Hata
AU - Rozemuller, Annemieke J. M.
AU - Ikram, M. Arfan
AU - van Duijn, Cornelia M.
N1 - Funding Information: Funding The National Prion Disease Registry is funded by the National Institute for Public Health and the Environment (RIVM), which is part from the Ministry for Health, Welfare and Sports (award number: 4410000033). Publisher Copyright: © 2021 BMJ Publishing Group Limited. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3/29
Y1 - 2021/3/29
N2 - Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, fatal, neurodegenerative disease caused by accumulation of abnormally folded prion protein. sCJD can have a long asymptomatic incubation period, with little known about this period. We describe the first-ever participant within the population-based Rotterdam Study diagnosed with sCJD. We retrieved clinical data from both the population-based Rotterdam Study and the National Prion Disease Registry. In 2011, a female participant of the Rotterdam Study was diagnosed with probable sCJD and registered into the Registry. Four months earlier, she was classified as having mild cognitive impairment based on assessment in the Rotterdam Study. Clinical deterioration was rapid, with the patient dying 7 months after the research centre visit. Postmortem brain autopsy confirmed the diagnosis of sCJD. In conclusion, we describe the first case diagnosed with sCJD who during diagnostic workup for sCJD was classified as having mild cognitive impairment in a population-based cohort study.
AB - Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, fatal, neurodegenerative disease caused by accumulation of abnormally folded prion protein. sCJD can have a long asymptomatic incubation period, with little known about this period. We describe the first-ever participant within the population-based Rotterdam Study diagnosed with sCJD. We retrieved clinical data from both the population-based Rotterdam Study and the National Prion Disease Registry. In 2011, a female participant of the Rotterdam Study was diagnosed with probable sCJD and registered into the Registry. Four months earlier, she was classified as having mild cognitive impairment based on assessment in the Rotterdam Study. Clinical deterioration was rapid, with the patient dying 7 months after the research centre visit. Postmortem brain autopsy confirmed the diagnosis of sCJD. In conclusion, we describe the first case diagnosed with sCJD who during diagnostic workup for sCJD was classified as having mild cognitive impairment in a population-based cohort study.
KW - alzheimer's type
KW - dementia
KW - memory disorders
KW - variant creutzfeld-jakob disease
UR - http://www.scopus.com/inward/record.url?scp=85103463148&partnerID=8YFLogxK
U2 - https://doi.org/10.1136/bcr-2020-235509
DO - https://doi.org/10.1136/bcr-2020-235509
M3 - Article
C2 - 33782059
SN - 1757-790X
VL - 14
JO - BMJ Case Reports
JF - BMJ Case Reports
IS - 3
M1 - e235509
ER -