Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis

P. Zhu; A. van der Ende; D. Falush; N. Brieske; G. Morelli; B. Linz; T. Popovic; I. G. Schuurman; R. A. Adegbola; K. Zurth; S. Gagneux; A. E. Platonov; J. Y. Riou; D. A. Caugant; P. Nicolas; M. Achtman

doi:https://doi.org/10.1073/pnas.061386098

Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis

P. Zhu, A. van der Ende, D. Falush, N. Brieske, G. Morelli, B. Linz, T. Popovic, I. G. Schuurman, R. A. Adegbola, K. Zurth, S. Gagneux, A. E. Platonov, J. Y. Riou, D. A. Caugant, P. Nicolas, M. Achtman

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Abstract

The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine "genoclouds" were identified, consisting of genotypes that were isolated repeatedly plus 48 descendent genotypes that were isolated rarely. These genoclouds have caused three pandemic waves of disease since the mid-1960s, the most recent of which was imported from East Asia to Europe and Africa in the mid-1990s. Many of the genotypes are escape variants, resulting from positive selection that we attribute to herd immunity. Despite positive selection, most escape variants are less fit than their parents and are lost because of competition and bottlenecks during spread from country to country. Competition between fit genotypes results in dramatic changes in population composition over short time periods

Original language	English
Pages (from-to)	5234-5239
Journal	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume	98
Issue number	9
DOIs	https://doi.org/10.1073/pnas.061386098
Publication status	Published - 2001

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https://doi.org/10.1073/pnas.061386098

Cite this

Zhu, P., van der Ende, A., Falush, D., Brieske, N., Morelli, G., Linz, B., Popovic, T., Schuurman, I. G., Adegbola, R. A., Zurth, K., Gagneux, S., Platonov, A. E., Riou, J. Y., Caugant, D. A., Nicolas, P., & Achtman, M. (2001). Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(9), 5234-5239. https://doi.org/10.1073/pnas.061386098

@article{a0608d073ace4cdbb9a5d8e13fb235e1,

title = "Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis",

abstract = "The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine {"}genoclouds{"} were identified, consisting of genotypes that were isolated repeatedly plus 48 descendent genotypes that were isolated rarely. These genoclouds have caused three pandemic waves of disease since the mid-1960s, the most recent of which was imported from East Asia to Europe and Africa in the mid-1990s. Many of the genotypes are escape variants, resulting from positive selection that we attribute to herd immunity. Despite positive selection, most escape variants are less fit than their parents and are lost because of competition and bottlenecks during spread from country to country. Competition between fit genotypes results in dramatic changes in population composition over short time periods",

author = "P. Zhu and {van der Ende}, A. and D. Falush and N. Brieske and G. Morelli and B. Linz and T. Popovic and Schuurman, {I. G.} and Adegbola, {R. A.} and K. Zurth and S. Gagneux and Platonov, {A. E.} and Riou, {J. Y.} and Caugant, {D. A.} and P. Nicolas and M. Achtman",

year = "2001",

doi = "https://doi.org/10.1073/pnas.061386098",

language = "English",

volume = "98",

pages = "5234--5239",

journal = "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA",

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Zhu, P, van der Ende, A, Falush, D, Brieske, N, Morelli, G, Linz, B, Popovic, T, Schuurman, IG, Adegbola, RA, Zurth, K, Gagneux, S, Platonov, AE, Riou, JY, Caugant, DA, Nicolas, P & Achtman, M 2001, 'Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 9, pp. 5234-5239. https://doi.org/10.1073/pnas.061386098

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T1 - Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis

AU - Zhu, P.

AU - van der Ende, A.

AU - Falush, D.

AU - Brieske, N.

AU - Morelli, G.

AU - Linz, B.

AU - Popovic, T.

AU - Schuurman, I. G.

AU - Adegbola, R. A.

AU - Zurth, K.

AU - Gagneux, S.

AU - Platonov, A. E.

AU - Riou, J. Y.

AU - Caugant, D. A.

AU - Nicolas, P.

AU - Achtman, M.

PY - 2001

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AB - The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine "genoclouds" were identified, consisting of genotypes that were isolated repeatedly plus 48 descendent genotypes that were isolated rarely. These genoclouds have caused three pandemic waves of disease since the mid-1960s, the most recent of which was imported from East Asia to Europe and Africa in the mid-1990s. Many of the genotypes are escape variants, resulting from positive selection that we attribute to herd immunity. Despite positive selection, most escape variants are less fit than their parents and are lost because of competition and bottlenecks during spread from country to country. Competition between fit genotypes results in dramatic changes in population composition over short time periods

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