TY - JOUR
T1 - Flow velocity and predictors of a suboptimal coronary flow velocity reserve after coronary balloon angioplasty
AU - Albertal, M.
AU - Regar, E.
AU - van Langenhove, G.
AU - Carlier, S. G.
AU - Serrano, P.
AU - Boersma, E.
AU - Bruyne, B.
AU - di Mario, C.
AU - Piek, J.
AU - Serruys, P. W.
PY - 2002
Y1 - 2002
N2 - This study was conducted to analyse flow velocity parameters and predictors of a suboptimal coronary flow reserve ( <2.5) following balloon angioplasty. Two hundred and twenty-five patients underwent sequential intracoronary Doppler as part of the DEBATE I study. Of these, 183, with complete angiography and Doppler at the 6-month follow-up, were included. Univariate and multivariate logistic analysis was performed to identify independent predictors of post-procedural suboptimal coronary flow reserve, defined as coronary flow reserve <2.5. Forty-eight per cent (n=88) of the patients achieved a suboptimal coronary flow reserve. These patients had higher baseline velocities (cm.s(-1)) before balloon angioplasty (18+/-9 vs 14+/-6, P=0.004), after balloon angioplasty (22+/-11 vs 14+/-5, P <0.001) and at follow-up (19+/-9 vs 16+/-6, P=0.011) than the optimal coronary flow reserve group. Although the suboptimal group had lower hyperaemic velocities (cm.s(-1)) after balloon angioplasty than the optimal group (42+/-17 vs 49+/-16, P=0.008), these velocities became similar at follow-up. Increasing age (odds ratio, OR 1.071, P=0.0002), female gender (OR 2.52, P=0.014) and increasing pre-procedural baseline average peak velocities (OR 1.056, P <0.001) were found to be independent predictors of a suboptimal coronary flow reserve following balloon angioplasty. A suboptimal coronary flow reserve was associated with (1) a chronically elevated baseline average peak velocity (2) a transient deficit in the hyperaemic average peak velocity (3) the elderly, and female gender
AB - This study was conducted to analyse flow velocity parameters and predictors of a suboptimal coronary flow reserve ( <2.5) following balloon angioplasty. Two hundred and twenty-five patients underwent sequential intracoronary Doppler as part of the DEBATE I study. Of these, 183, with complete angiography and Doppler at the 6-month follow-up, were included. Univariate and multivariate logistic analysis was performed to identify independent predictors of post-procedural suboptimal coronary flow reserve, defined as coronary flow reserve <2.5. Forty-eight per cent (n=88) of the patients achieved a suboptimal coronary flow reserve. These patients had higher baseline velocities (cm.s(-1)) before balloon angioplasty (18+/-9 vs 14+/-6, P=0.004), after balloon angioplasty (22+/-11 vs 14+/-5, P <0.001) and at follow-up (19+/-9 vs 16+/-6, P=0.011) than the optimal coronary flow reserve group. Although the suboptimal group had lower hyperaemic velocities (cm.s(-1)) after balloon angioplasty than the optimal group (42+/-17 vs 49+/-16, P=0.008), these velocities became similar at follow-up. Increasing age (odds ratio, OR 1.071, P=0.0002), female gender (OR 2.52, P=0.014) and increasing pre-procedural baseline average peak velocities (OR 1.056, P <0.001) were found to be independent predictors of a suboptimal coronary flow reserve following balloon angioplasty. A suboptimal coronary flow reserve was associated with (1) a chronically elevated baseline average peak velocity (2) a transient deficit in the hyperaemic average peak velocity (3) the elderly, and female gender
U2 - https://doi.org/10.1053/euhj.2001.2708
DO - https://doi.org/10.1053/euhj.2001.2708
M3 - Article
C2 - 11785995
SN - 0195-668X
VL - 23
SP - 133
EP - 138
JO - European Heart journal
JF - European Heart journal
IS - 2
ER -