TY - JOUR
T1 - Fluid and solute transport in CAPD patients using ultralow sodium dialysate
AU - Imholz, A. L.
AU - Koomen, G. C.
AU - Struijk, D. G.
AU - Arisz, L.
AU - Krediet, R. T.
PY - 1994
Y1 - 1994
N2 - Transcapillary ultrafiltration during CAPD is determined by the ultrafiltration coefficient of the peritoneal membrane and by Starling forces, the latter being mainly determined by the osmolality of the dialysate. Dialysate sodium concentration decreases during a dwell, implying that: (1) sodium passes the peritoneal membrane to a lesser extent than H2O, and (2) more H2O than sodium is removed in overhydrated patients. We therefore compared two dialysate solutions with similar osmolality, but different sodium concentration (Na+ 129 mmol/liter and 102 mmol/liter). Two peritoneal permeability tests (2 x 6 hrs, dextran 70 as volume marker) with an interval of two days were performed in 10 CAPD patients. Transcapillary ultrafiltration rate was higher with ultralow sodium dialysate (USD) than normal sodium dialysate (NSD): 1.80 +/- 0.16 ml/min versus 1.58 +/- 0.18 (P < 0.01). It was especially higher during the last two hours of the dwell: 0.49 +/- 0.12 ml/min (USD) versus 0.27 +/- 0.13 (NSD). The effective lymphatic absorption rate was not different: 1.01 +/- 0.12 ml/min (USD) versus 1.05 +/- 0.09 (NSD). Using two different kinetic models, the reflection coefficients for glucose, sodium and chloride were 0.032, 0.029 and 0.027 (for the convection model) and 0.033, 0.030 and 0.027 (for the diffusion model). As a consequence the decline in osmotic pressure was more gradual during the exchange with USD. The peritoneal membrane characteristics, that is the effective peritoneal surface area and the peritoneal restriction coefficient, were not altered by the composition of the dialysate.(ABSTRACT TRUNCATED AT 250 WORDS)
AB - Transcapillary ultrafiltration during CAPD is determined by the ultrafiltration coefficient of the peritoneal membrane and by Starling forces, the latter being mainly determined by the osmolality of the dialysate. Dialysate sodium concentration decreases during a dwell, implying that: (1) sodium passes the peritoneal membrane to a lesser extent than H2O, and (2) more H2O than sodium is removed in overhydrated patients. We therefore compared two dialysate solutions with similar osmolality, but different sodium concentration (Na+ 129 mmol/liter and 102 mmol/liter). Two peritoneal permeability tests (2 x 6 hrs, dextran 70 as volume marker) with an interval of two days were performed in 10 CAPD patients. Transcapillary ultrafiltration rate was higher with ultralow sodium dialysate (USD) than normal sodium dialysate (NSD): 1.80 +/- 0.16 ml/min versus 1.58 +/- 0.18 (P < 0.01). It was especially higher during the last two hours of the dwell: 0.49 +/- 0.12 ml/min (USD) versus 0.27 +/- 0.13 (NSD). The effective lymphatic absorption rate was not different: 1.01 +/- 0.12 ml/min (USD) versus 1.05 +/- 0.09 (NSD). Using two different kinetic models, the reflection coefficients for glucose, sodium and chloride were 0.032, 0.029 and 0.027 (for the convection model) and 0.033, 0.030 and 0.027 (for the diffusion model). As a consequence the decline in osmotic pressure was more gradual during the exchange with USD. The peritoneal membrane characteristics, that is the effective peritoneal surface area and the peritoneal restriction coefficient, were not altered by the composition of the dialysate.(ABSTRACT TRUNCATED AT 250 WORDS)
U2 - https://doi.org/10.1038/ki.1994.279
DO - https://doi.org/10.1038/ki.1994.279
M3 - Article
C2 - 7967344
SN - 0085-2538
VL - 46
SP - 333
EP - 340
JO - Kidney International
JF - Kidney International
IS - 2
ER -