TY - JOUR
T1 - Foot-ankle therapeutic exercise program can improve gait speed in people with diabetic neuropathy
T2 - a randomized controlled trial
AU - Monteiro, Renan L.
AU - Ferreira, Jane S. S. P.
AU - Silva, Érica Q.
AU - Cruvinel-Júnior, Ronaldo H.
AU - Veríssimo, Jady L.
AU - Bus, Sicco A.
AU - Sacco, Isabel C. N.
N1 - Funding Information: This work was supported by Sao Paulo Research Foundation [FAPESP 2017/17848-3] and by the National Council for Scientific and Technological Development, Brazil (CNPq) [28/2018 FOCA Trial 407252/2018-5]. Ferreira and Cruvinel were supported by FAPESP [2019/02522-0; 2019/06405-9]; and Queiroz was supported by the Agency Coordination of Improvement of Higher Education Personnel (CAPES, financial Code 001). Sacco is supported as a fellow researcher in CNPq, Brazil (Processes 304124/2018-4). The funders had no role in the design, execution, interpretation, or writing of the study and did not have any authority over any study activity or in the decision to submit the report for publication. Funding Information: The authors would like to thank Full Professor Ana Claudia Latronico Xavier for supporting us with a database of diabetic patients at Hospital das Clínicas, Faculty of Medicine, University of São Paulo. Publisher Copyright: © 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - This study sought to determine whether a foot-ankle therapeutic exercise program can improve daily physical activity (i.e. number of steps) and fast and self-selected gait speed in people with diabetic peripheral neuropathy (DPN). In this single-blind randomized controlled trial and intention-to-treat analysis, 78 volunteers with DPN were allocated into a control group, which received usual care, and an intervention group (IG), which received usual care plus a 12-week foot-ankle exercise program. The adherence at 12 weeks rate in the IG was 92.3% (36 participants) and the dropout was 5.1% in the control group (2 participants). The number of steps and self-selected gait speed did not change significantly in either group (p > 0.05), although a 1,365-step difference between groups were observed at 1-year followup. The 12-week foot-ankle therapeutic exercises improved significantly fast-gait speed (primary outcome) (p = 0.020), ankle range of motion (p = 0.048), and vibration perception (secondary outcomes) (p = 0.030), compared with usual-care at 12 weeks. At 24 weeks, the IG showed better quality of life than controls (p = 0.048). At 1-year, fast-gait speed and vibration perception remained higher in the IG versus controls. Overall, the program may be a complementary treatment strategy for improving musculoskeletal and functional deficits related to DPN.Trial registration ClinicalTrials.gov NCT02790931 (06/06/2016).
AB - This study sought to determine whether a foot-ankle therapeutic exercise program can improve daily physical activity (i.e. number of steps) and fast and self-selected gait speed in people with diabetic peripheral neuropathy (DPN). In this single-blind randomized controlled trial and intention-to-treat analysis, 78 volunteers with DPN were allocated into a control group, which received usual care, and an intervention group (IG), which received usual care plus a 12-week foot-ankle exercise program. The adherence at 12 weeks rate in the IG was 92.3% (36 participants) and the dropout was 5.1% in the control group (2 participants). The number of steps and self-selected gait speed did not change significantly in either group (p > 0.05), although a 1,365-step difference between groups were observed at 1-year followup. The 12-week foot-ankle therapeutic exercises improved significantly fast-gait speed (primary outcome) (p = 0.020), ankle range of motion (p = 0.048), and vibration perception (secondary outcomes) (p = 0.030), compared with usual-care at 12 weeks. At 24 weeks, the IG showed better quality of life than controls (p = 0.048). At 1-year, fast-gait speed and vibration perception remained higher in the IG versus controls. Overall, the program may be a complementary treatment strategy for improving musculoskeletal and functional deficits related to DPN.Trial registration ClinicalTrials.gov NCT02790931 (06/06/2016).
UR - http://www.scopus.com/inward/record.url?scp=85129509891&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41598-022-11745-0
DO - https://doi.org/10.1038/s41598-022-11745-0
M3 - Article
C2 - 35534614
SN - 2045-2322
VL - 12
SP - 7561
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 7561
ER -