TY - JOUR
T1 - FOS Rearrangement and Expression in Cementoblastoma
AU - Lam, Suk Wai
AU - Cleven, Arjen H. G.
AU - Briaire-de Bruijn, Inge H.
AU - Schreuder, Willem H.
AU - Kroon, Herman M.
AU - Savci-Heijink, Dilara C.
AU - Suurmeijer, Albert J. H.
AU - Szuhai, Karoly
AU - Bovée, Judith V. M. G.
AU - Baumhoer, Daniel
N1 - Publisher Copyright: © 2021 Wolters Kluwer Health, Inc. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Cementoblastomas are rare odontogenic tumors developing in close proximity to the roots of teeth. Due to their striking morphologic resemblance to osteoblastomas of the peripheral skeleton, we set out to determine whether cementoblastomas harbor the same FOS rearrangements with overexpression of c-FOS as has recently been described for osteoblastomas. In total, 16 cementoblastomas were analyzed for FOS expression by immunohistochemistry and for FOS rearrangements by fluorescence in situ hybridization (FISH). We observed strong and diffuse staining of c-FOS in 71% of cementoblastomas and identified a FOS rearrangement in all cases (n=3) applicable for FISH. In the remaining cases, FISH failed due to decalcification. Cementoblastomas harbor similar FOS rearrangements and show overexpression of c-FOS like osteoblastomas, suggesting that both entities might represent parts of the spectrum of the same disease.
AB - Cementoblastomas are rare odontogenic tumors developing in close proximity to the roots of teeth. Due to their striking morphologic resemblance to osteoblastomas of the peripheral skeleton, we set out to determine whether cementoblastomas harbor the same FOS rearrangements with overexpression of c-FOS as has recently been described for osteoblastomas. In total, 16 cementoblastomas were analyzed for FOS expression by immunohistochemistry and for FOS rearrangements by fluorescence in situ hybridization (FISH). We observed strong and diffuse staining of c-FOS in 71% of cementoblastomas and identified a FOS rearrangement in all cases (n=3) applicable for FISH. In the remaining cases, FISH failed due to decalcification. Cementoblastomas harbor similar FOS rearrangements and show overexpression of c-FOS like osteoblastomas, suggesting that both entities might represent parts of the spectrum of the same disease.
KW - FOS
KW - bone tumor
KW - cementoblastoma
UR - http://www.scopus.com/inward/record.url?scp=85104209559&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/PAS.0000000000001695
DO - https://doi.org/10.1097/PAS.0000000000001695
M3 - Article
C2 - 33653978
SN - 0147-5185
VL - 45
SP - 690
EP - 693
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 5
ER -