Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits

J.M. Oosterman, E.J.W. van Someren, R. L. Vogels, B. van Harten, E.J.A. Scherder

Research output: Contribution to journalArticleAcademicpeer-review

144 Citations (Scopus)

Abstract

Aging affects both cognitive performance and the sleep-wake rhythm. The recent surge of studies that support a role of sleep for cognitive performance in healthy young adults suggests that disturbed sleep-wake rhythms may contribute to 'age-related' cognitive decline. This relationship has however not previously been extensively investigated. The present correlational study integrated a battery of standardized cognitive tests to investigate the association of mental speed, memory, and executive function with actigraphically recorded sleep-wake rhythms in 144 home-dwelling elderly participants aged 69.5 ± 8.5 (mean ± SD). Multiple regression analyses showed that the partial correlations of the fragmentation of the sleep-wake rhythm with each of the three cognitive domains (r = -0.16, -0.19, and -0.16 respectively) were significant. These associations were independent from main effects of age, implying that a unique relationship between the rest-activity rhythm and cognitive performance is present in elderly people. © 2009 European Sleep Research Society.
Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalJournal of sleep research
Volume18
Issue number1
DOIs
Publication statusPublished - 2009

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