TY - JOUR
T1 - From “East vs West” towards international multidisciplinary collaboration: An appraisal of lateral lymph nodes in rectal cancer
AU - Sluckin, Tania C.
AU - Hazen, Sanne-Marije J. A.
AU - Kusters, Miranda
N1 - Publisher Copyright: © 2021 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterology
PY - 2021/11
Y1 - 2021/11
N2 - Western and Eastern practices have traditionally differed in their approach to treating lateral lymph nodes in rectal cancer. While Western clinicians have primarily favored neoadjuvant (chemo)radiotherapy to sterilize lateral compartments, Eastern physicians have often opted for the surgical removed of lymphatic tissue with a lateral lymph node dissection without neoadjuvant treatment. The literature suggests similar oncological outcomes for these two separate techniques, while tangible differences exist. The combination of these paradigms may be beneficial in reducing overall morbidity while sustaining low recurrence rates. This article considers traditional Eastern and Western perspectives, discusses nodal features important for predicting malignancy and attempts to stimulate international, multidisciplinary consensus and collaboration.
AB - Western and Eastern practices have traditionally differed in their approach to treating lateral lymph nodes in rectal cancer. While Western clinicians have primarily favored neoadjuvant (chemo)radiotherapy to sterilize lateral compartments, Eastern physicians have often opted for the surgical removed of lymphatic tissue with a lateral lymph node dissection without neoadjuvant treatment. The literature suggests similar oncological outcomes for these two separate techniques, while tangible differences exist. The combination of these paradigms may be beneficial in reducing overall morbidity while sustaining low recurrence rates. This article considers traditional Eastern and Western perspectives, discusses nodal features important for predicting malignancy and attempts to stimulate international, multidisciplinary consensus and collaboration.
KW - lateral lymph node dissection
KW - lateral lymph nodes
KW - neoadjuvant treatment
UR - http://www.scopus.com/inward/record.url?scp=85112598594&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/ags3.12490
DO - https://doi.org/10.1002/ags3.12490
M3 - Review article
C2 - 34755004
SN - 2475-0328
VL - 5
SP - 731
EP - 737
JO - Annals of Gastroenterological Surgery
JF - Annals of Gastroenterological Surgery
IS - 6
ER -