From stem cells to lymphocytes: biology and transplantation

H L Aguila; K Akashi; J Domen; K L Gandy; E Lagasse; R E Mebius; S J Morrison; J Shizuru; S Strober; N Uchida; D E Wright; I L Weissman

doi:https://doi.org/10.1111/j.1600-065X.1997.tb00971.x

From stem cells to lymphocytes: biology and transplantation

H L Aguila, K Akashi, J Domen, K L Gandy, E Lagasse, R E Mebius, S J Morrison, J Shizuru, S Strober, N Uchida, D E Wright, I L Weissman

Research output: Contribution to journal › Review article › Academic › peer-review

63 Citations (Scopus)

Abstract

We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

Original language	English
Pages (from-to)	13-40
Number of pages	28
Journal	Immunological reviews
Volume	157
DOIs	https://doi.org/10.1111/j.1600-065X.1997.tb00971.x
Publication status	Published - Jun 1997

Keywords

Animals
Hematopoietic Stem Cell Transplantation/history
Hematopoietic Stem Cells/immunology
History, 20th Century
Humans
Transplantation Immunology

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https://doi.org/10.1111/j.1600-065X.1997.tb00971.x

Cite this

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title = "From stem cells to lymphocytes: biology and transplantation",

abstract = "We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.",

keywords = "Animals, Hematopoietic Stem Cell Transplantation/history, Hematopoietic Stem Cells/immunology, History, 20th Century, Humans, Transplantation Immunology",

author = "Aguila, {H L} and K Akashi and J Domen and Gandy, {K L} and E Lagasse and Mebius, {R E} and Morrison, {S J} and J Shizuru and S Strober and N Uchida and Wright, {D E} and Weissman, {I L}",

year = "1997",

month = jun,

doi = "https://doi.org/10.1111/j.1600-065X.1997.tb00971.x",

language = "English",

volume = "157",

pages = "13--40",

journal = "Immunological reviews",

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publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - From stem cells to lymphocytes

T2 - biology and transplantation

AU - Aguila, H L

AU - Akashi, K

AU - Domen, J

AU - Gandy, K L

AU - Lagasse, E

AU - Mebius, R E

AU - Morrison, S J

AU - Shizuru, J

AU - Strober, S

AU - Uchida, N

AU - Wright, D E

AU - Weissman, I L

PY - 1997/6

Y1 - 1997/6

N2 - We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

AB - We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

KW - Animals

KW - Hematopoietic Stem Cell Transplantation/history

KW - Hematopoietic Stem Cells/immunology

KW - History, 20th Century

KW - Humans

KW - Transplantation Immunology

U2 - https://doi.org/10.1111/j.1600-065X.1997.tb00971.x

DO - https://doi.org/10.1111/j.1600-065X.1997.tb00971.x

M3 - Review article

C2 - 9255619

SN - 0105-2896

VL - 157

SP - 13

EP - 40

JO - Immunological reviews

JF - Immunological reviews

ER -