TY - JOUR
T1 - Fulminant hepatitis during treatment with rifampicin, pyrazinamid and ethambutol
AU - van Aalderen, W. M.
AU - Knoester, H.
AU - Knol, K.
PY - 1987
Y1 - 1987
N2 - A 10-year-old girl with cervical tuberculosis was treated with Isoniazid, Rimfampicin and Ethambutol. After 2 weeks of treatment a hepatotoxic reaction developed. Withdrawal of therapy resulted in complete clinical improvement and in normalization of all laboratory measurements. Treatment was restarted with Rifampicin, Pyrazinamid and Ethambutol. Liver enzyme levels were monitored weekly. Seven weeks after this three-drug regiment was started, all therapy was discontinued because of elevated liver enzyme levels. However, the patient died 2 weeks later of progressive fulminant hepatitis
AB - A 10-year-old girl with cervical tuberculosis was treated with Isoniazid, Rimfampicin and Ethambutol. After 2 weeks of treatment a hepatotoxic reaction developed. Withdrawal of therapy resulted in complete clinical improvement and in normalization of all laboratory measurements. Treatment was restarted with Rifampicin, Pyrazinamid and Ethambutol. Liver enzyme levels were monitored weekly. Seven weeks after this three-drug regiment was started, all therapy was discontinued because of elevated liver enzyme levels. However, the patient died 2 weeks later of progressive fulminant hepatitis
U2 - https://doi.org/10.1007/BF00716476
DO - https://doi.org/10.1007/BF00716476
M3 - Comment/Letter to the editor
C2 - 3595648
SN - 0340-6199
VL - 146
SP - 290
EP - 291
JO - European journal of pediatrics
JF - European journal of pediatrics
IS - 3
ER -