Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki; Sara Gandolfi; Ricardo De Matos Simoes; Geoffrey M. Matthews; Dennis Buckley; Joseline Raja; Quinlan L. Sievers; Olga Dashevsky; Haley Poarch; Huihui Tang; Megan Bariteau; Michal Sheffer; Sondra L. Downey-Kopyscinski; Paul Hengeveld; Brian Glassner; Eugen Dhimolea; Christopher J. Ott; Tinghu Zhang; Nicholas P. Kwiatkowski; Jacob P. Laubach; Robert L. Schlossman; Paul G. Richardson; Aedin Culhane; Richard W. J. Groen; Eric Fischer; Benjamin L. Ebert; Francisca Vazquez; Aviad Tsherniak; William C. Hahn; Joan Levy; Daniel Auclair; Jonathan D. Licht; Jonathan J. Keats; Lawrence H. Boise; James Bradner; Nathanael Gray; Constantine S. Mitsiades

doi:https://doi.org/10.1182/blood-2019-130549

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, Sara Gandolfi, Ricardo De Matos Simoes, Geoffrey M. Matthews, Dennis Buckley, Joseline Raja, Quinlan L. Sievers, Olga Dashevsky, Haley Poarch, Huihui Tang, Megan Bariteau, Michal Sheffer, Sondra L. Downey-Kopyscinski, Paul Hengeveld, Brian Glassner, Eugen Dhimolea, Christopher J. Ott, Tinghu Zhang, Nicholas P. Kwiatkowski, Jacob P. LaubachRobert L. Schlossman, Paul G. Richardson, Aedin Culhane, Richard W. J. Groen, Eric Fischer, Benjamin L. Ebert, Francisca Vazquez, Aviad Tsherniak, William C. Hahn, Joan Levy, Daniel Auclair, Jonathan D. Licht, Jonathan J. Keats, Lawrence H. Boise, James Bradner, Nathanael Gray, Constantine S. Mitsiades

Research output: Contribution to journal › Meeting Abstract › Academic

Original language	English
Journal	Blood
Volume	134
DOIs	https://doi.org/10.1182/blood-2019-130549
Publication status	Published - 13 Nov 2019

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https://doi.org/10.1182/blood-2019-130549

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Shirasaki, R., Gandolfi, S., Simoes, R. D. M., Matthews, G. M., Buckley, D., Raja, J., Sievers, Q. L., Dashevsky, O., Poarch, H., Tang, H., Bariteau, M., Sheffer, M., Downey-Kopyscinski, S. L., Hengeveld, P., Glassner, B., Dhimolea, E., Ott, C. J., Zhang, T., Kwiatkowski, N. P., ... Mitsiades, C. S. (2019). Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins. Blood, 134. https://doi.org/10.1182/blood-2019-130549

@article{bbd7368ab6dd4e42aac93f2397f4d8c6,

title = "Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins",

author = "Ryosuke Shirasaki and Sara Gandolfi and Simoes, {Ricardo De Matos} and Matthews, {Geoffrey M.} and Dennis Buckley and Joseline Raja and Sievers, {Quinlan L.} and Olga Dashevsky and Haley Poarch and Huihui Tang and Megan Bariteau and Michal Sheffer and Downey-Kopyscinski, {Sondra L.} and Paul Hengeveld and Brian Glassner and Eugen Dhimolea and Ott, {Christopher J.} and Tinghu Zhang and Kwiatkowski, {Nicholas P.} and Laubach, {Jacob P.} and Schlossman, {Robert L.} and Richardson, {Paul G.} and Aedin Culhane and Groen, {Richard W. J.} and Eric Fischer and Ebert, {Benjamin L.} and Francisca Vazquez and Aviad Tsherniak and Hahn, {William C.} and Joan Levy and Daniel Auclair and Licht, {Jonathan D.} and Keats, {Jonathan J.} and Boise, {Lawrence H.} and James Bradner and Nathanael Gray and Mitsiades, {Constantine S.}",

year = "2019",

month = nov,

day = "13",

doi = "https://doi.org/10.1182/blood-2019-130549",

language = "English",

volume = "134",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

}

Shirasaki, R, Gandolfi, S, Simoes, RDM, Matthews, GM, Buckley, D, Raja, J, Sievers, QL, Dashevsky, O, Poarch, H, Tang, H, Bariteau, M, Sheffer, M, Downey-Kopyscinski, SL, Hengeveld, P, Glassner, B, Dhimolea, E, Ott, CJ, Zhang, T, Kwiatkowski, NP, Laubach, JP, Schlossman, RL, Richardson, PG, Culhane, A, Groen, RWJ, Fischer, E, Ebert, BL, Vazquez, F, Tsherniak, A, Hahn, WC, Levy, J, Auclair, D, Licht, JD, Keats, JJ, Boise, LH, Bradner, J, Gray, N & Mitsiades, CS 2019, 'Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins', Blood, vol. 134. https://doi.org/10.1182/blood-2019-130549

TY - JOUR

T1 - Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

AU - Shirasaki, Ryosuke

AU - Gandolfi, Sara

AU - Simoes, Ricardo De Matos

AU - Matthews, Geoffrey M.

AU - Buckley, Dennis

AU - Raja, Joseline

AU - Sievers, Quinlan L.

AU - Dashevsky, Olga

AU - Poarch, Haley

AU - Tang, Huihui

AU - Bariteau, Megan

AU - Sheffer, Michal

AU - Downey-Kopyscinski, Sondra L.

AU - Hengeveld, Paul

AU - Glassner, Brian

AU - Dhimolea, Eugen

AU - Ott, Christopher J.

AU - Zhang, Tinghu

AU - Kwiatkowski, Nicholas P.

AU - Laubach, Jacob P.

AU - Schlossman, Robert L.

AU - Richardson, Paul G.

AU - Culhane, Aedin

AU - Groen, Richard W. J.

AU - Fischer, Eric

AU - Ebert, Benjamin L.

AU - Vazquez, Francisca

AU - Tsherniak, Aviad

AU - Hahn, William C.

AU - Levy, Joan

AU - Auclair, Daniel

AU - Licht, Jonathan D.

AU - Keats, Jonathan J.

AU - Boise, Lawrence H.

AU - Bradner, James

AU - Gray, Nathanael

AU - Mitsiades, Constantine S.

PY - 2019/11/13

Y1 - 2019/11/13

U2 - https://doi.org/10.1182/blood-2019-130549

DO - https://doi.org/10.1182/blood-2019-130549

M3 - Meeting Abstract

SN - 0006-4971

VL - 134

JO - Blood

JF - Blood

ER -