Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability

D. Ruano, G.R. Abecasis, B. Glaser, E.S. Lips, L.N. Cornelisse, A.P.H. de Jong, D.M. Evans, D.G. Smith, N.J. Thimpson, A.B. Smit, P. Heutink, M. Verhage, D. Posthuma

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Abstract

Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation. This implies that hundreds of genes of small effect may be of importance for cognitive ability. We applied an innovative method in which we tested for the effect of groups of genes defined according to cellular function (functional gene group analysis). Using an initial sample of 627 subjects, this functional gene group analysis detected that synaptic heterotrimeric guanine nucleotide binding proteins (G proteins) play an important role in cognitive ability (P
Original languageEnglish
Pages (from-to)113-125
JournalAmerican journal of human genetics
Volume86
Issue number2
DOIs
Publication statusPublished - 2010

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