TY - JOUR
T1 - Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care
AU - Breiteneder, Heimo
AU - Diamant, Zuzana
AU - Eiwegger, Thomas
AU - Fokkens, Wytske J.
AU - Traidl-Hoffmann, Claudia
AU - Nadeau, Kari
AU - O’Hehir, Robyn E.
AU - O’Mahony, Liam
AU - Pfaar, Oliver
AU - Torres, Maria J.
AU - Wang, De Yun
AU - Zhang, Luo
AU - Akdis, Cezmi A.
PY - 2019
Y1 - 2019
N2 - The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail. In the third section, unmet needs and future research areas for the treatment of allergic diseases are highlighted with topics on food allergy, biologics, small molecules, and novel therapeutic concepts in allergen-specific immunotherapy for airway disease. Unknowns and future research needs are discussed at the end of each subsection.
AB - The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail. In the third section, unmet needs and future research areas for the treatment of allergic diseases are highlighted with topics on food allergy, biologics, small molecules, and novel therapeutic concepts in allergen-specific immunotherapy for airway disease. Unknowns and future research needs are discussed at the end of each subsection.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076352199&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31056763
U2 - https://doi.org/10.1111/all.13851
DO - https://doi.org/10.1111/all.13851
M3 - Review article
C2 - 31056763
SN - 0105-4538
VL - 74
SP - 2293
EP - 2311
JO - Allergy
JF - Allergy
IS - 12
ER -