TY - JOUR
T1 - Gender differences in the long QT syndrome: effects of beta-adrenoceptor blockade
AU - Conrath, Chantal E.
AU - Wilde, Arthur A. M.
AU - Jongbloed, Rosalie J. E.
AU - Alders, Mariëlle
AU - van Langen, Irene M.
AU - van Tintelen, J. Peter
AU - Doevendans, Pieter A.
AU - Opthof, Tobias
PY - 2002
Y1 - 2002
N2 - Background: Gender differences have been reported in patients with the congenital long QT syndrome (LQTS). We analyzed whether electrocardiographic differences existed in females, males, girls and boys in response to beta-adrenoceptor blockade. Methods: 12-lead ECGs before and during beta-adrenoceptor blockade were collected in 87 genotyped LQTS patients (48 women, 14 men, 12 girls and 13 boys). Up to three QTc intervals were determined in each lead of the ECG.V4 was used for QT/QTc analysis. Difference between longest and shortest QT interval was taken as a measure for dispersion of QT intervals. Results: (1) Adult males had the greatest shortening of the QTc interval upon treatment with P-adrenoceptor blockade. During treatment, adult males with LQTS(1) (mutation in the KCNQ1 gene, affecting I-Ks current) were found to have shorter QTc intervals than adult females; this difference did not exist in LQTS(2) patients (mutation in the HERG gene, affecting I-Kr current). (2) Female LQTS(2) patients had a 50% larger dispersion than female LQTS(1) patients both before and during treatment. (3) Adult male LQTS(1) patients, constitute the only patient group with a marked decrease in QTc intervals and dispersion associated with a 100% efficacy of treatment in response to beta-adrenoceptor blockade. Conclusions: These findings indicate that, in addition to underlying differences in repolarization between men and women, cardiae electrophysiological responses to beta-adrenoceptor blockade can be modulated by gender-related factors. (C) 2002 Elsevier Science B.V. All rights reserved
AB - Background: Gender differences have been reported in patients with the congenital long QT syndrome (LQTS). We analyzed whether electrocardiographic differences existed in females, males, girls and boys in response to beta-adrenoceptor blockade. Methods: 12-lead ECGs before and during beta-adrenoceptor blockade were collected in 87 genotyped LQTS patients (48 women, 14 men, 12 girls and 13 boys). Up to three QTc intervals were determined in each lead of the ECG.V4 was used for QT/QTc analysis. Difference between longest and shortest QT interval was taken as a measure for dispersion of QT intervals. Results: (1) Adult males had the greatest shortening of the QTc interval upon treatment with P-adrenoceptor blockade. During treatment, adult males with LQTS(1) (mutation in the KCNQ1 gene, affecting I-Ks current) were found to have shorter QTc intervals than adult females; this difference did not exist in LQTS(2) patients (mutation in the HERG gene, affecting I-Kr current). (2) Female LQTS(2) patients had a 50% larger dispersion than female LQTS(1) patients both before and during treatment. (3) Adult male LQTS(1) patients, constitute the only patient group with a marked decrease in QTc intervals and dispersion associated with a 100% efficacy of treatment in response to beta-adrenoceptor blockade. Conclusions: These findings indicate that, in addition to underlying differences in repolarization between men and women, cardiae electrophysiological responses to beta-adrenoceptor blockade can be modulated by gender-related factors. (C) 2002 Elsevier Science B.V. All rights reserved
U2 - https://doi.org/10.1016/S0008-6363(01)00477-1
DO - https://doi.org/10.1016/S0008-6363(01)00477-1
M3 - Article
C2 - 11861047
SN - 0008-6363
VL - 53
SP - 770
EP - 776
JO - Cardiovascular research
JF - Cardiovascular research
IS - 3
ER -