Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

J. Bras; R. Guerreiro; L. Darwent; L. Parkkinen; O. Ansorge; V. Escott-Price; D.G. Hernandez; M.A. Nalls; L.N. Clark; L.S. Honig; K. Marder; W.M. van der Flier; A.W. Lemstra; P. Scheltens; E. Rogaeva; P. St George-Hyslop; E. Londos; H. Zetterberg; S. Ortega-Cubero; P. Pastor; T.J. Ferman; N.R. Graff-Radford; O.A. Ross; I. Barber; A. Braae; K. Brown; K. Morgan; W. Maetzler; D. Berg; C. Troakes; S. Al-Sarraj; T. Lashley; Y. Compta; T. Revesz; A. Lees; N. Cairns; G.M. Halliday; D. Mann; S. Pickering-Brown; D.W. Dickson; A. Singleton; J. Hardy

doi:https://doi.org/10.1093/hmg/ddu334

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

J. Bras, R. Guerreiro, L. Darwent, L. Parkkinen, O. Ansorge, V. Escott-Price, D.G. Hernandez, M.A. Nalls, L.N. Clark, L.S. Honig, K. Marder, W.M. van der Flier, A.W. Lemstra, P. Scheltens, E. Rogaeva, P. St George-Hyslop, E. Londos, H. Zetterberg, S. Ortega-Cubero, P. PastorT.J. Ferman, N.R. Graff-Radford, O.A. Ross, I. Barber, A. Braae, K. Brown, K. Morgan, W. Maetzler, D. Berg, C. Troakes, S. Al-Sarraj, T. Lashley, Y. Compta, T. Revesz, A. Lees, N. Cairns, G.M. Halliday, D. Mann, S. Pickering-Brown, D.W. Dickson, A. Singleton, J. Hardy

Neurology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

168 Citations (Scopus)

Original language	English
Pages (from-to)	6139-6146
Journal	Human Molecular Genetics
Volume	23
Issue number	23
DOIs	https://doi.org/10.1093/hmg/ddu334
Publication status	Published - 2014

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Cite this

Bras, J., Guerreiro, R., Darwent, L., Parkkinen, L., Ansorge, O., Escott-Price, V., Hernandez, D. G., Nalls, M. A., Clark, L. N., Honig, L. S., Marder, K., van der Flier, W. M., Lemstra, A. W., Scheltens, P., Rogaeva, E., St George-Hyslop, P., Londos, E., Zetterberg, H., Ortega-Cubero, S., ... Hardy, J. (2014). Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Human Molecular Genetics, 23(23), 6139-6146. https://doi.org/10.1093/hmg/ddu334

@article{f37ad3bb1ac742fb8ea8379014a62fe5,

title = "Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies",

author = "J. Bras and R. Guerreiro and L. Darwent and L. Parkkinen and O. Ansorge and V. Escott-Price and D.G. Hernandez and M.A. Nalls and L.N. Clark and L.S. Honig and K. Marder and {van der Flier}, W.M. and A.W. Lemstra and P. Scheltens and E. Rogaeva and {St George-Hyslop}, P. and E. Londos and H. Zetterberg and S. Ortega-Cubero and P. Pastor and T.J. Ferman and N.R. Graff-Radford and O.A. Ross and I. Barber and A. Braae and K. Brown and K. Morgan and W. Maetzler and D. Berg and C. Troakes and S. Al-Sarraj and T. Lashley and Y. Compta and T. Revesz and A. Lees and N. Cairns and G.M. Halliday and D. Mann and S. Pickering-Brown and D.W. Dickson and A. Singleton and J. Hardy",

year = "2014",

doi = "https://doi.org/10.1093/hmg/ddu334",

language = "English",

volume = "23",

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journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

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Bras, J, Guerreiro, R, Darwent, L, Parkkinen, L, Ansorge, O, Escott-Price, V, Hernandez, DG, Nalls, MA, Clark, LN, Honig, LS, Marder, K, van der Flier, WM , Lemstra, AW , Scheltens, P, Rogaeva, E, St George-Hyslop, P, Londos, E, Zetterberg, H, Ortega-Cubero, S, Pastor, P, Ferman, TJ, Graff-Radford, NR, Ross, OA, Barber, I, Braae, A, Brown, K, Morgan, K, Maetzler, W, Berg, D, Troakes, C, Al-Sarraj, S, Lashley, T, Compta, Y, Revesz, T, Lees, A, Cairns, N, Halliday, GM, Mann, D, Pickering-Brown, S, Dickson, DW, Singleton, A & Hardy, J 2014, 'Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies', Human Molecular Genetics, vol. 23, no. 23, pp. 6139-6146. https://doi.org/10.1093/hmg/ddu334

TY - JOUR

T1 - Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

AU - Bras, J.

AU - Guerreiro, R.

AU - Darwent, L.

AU - Parkkinen, L.

AU - Ansorge, O.

AU - Escott-Price, V.

AU - Hernandez, D.G.

AU - Nalls, M.A.

AU - Clark, L.N.

AU - Honig, L.S.

AU - Marder, K.

AU - van der Flier, W.M.

AU - Lemstra, A.W.

AU - Scheltens, P.

AU - Rogaeva, E.

AU - St George-Hyslop, P.

AU - Londos, E.

AU - Zetterberg, H.

AU - Ortega-Cubero, S.

AU - Pastor, P.

AU - Ferman, T.J.

AU - Graff-Radford, N.R.

AU - Ross, O.A.

AU - Barber, I.

AU - Braae, A.

AU - Brown, K.

AU - Morgan, K.

AU - Maetzler, W.

AU - Berg, D.

AU - Troakes, C.

AU - Al-Sarraj, S.

AU - Lashley, T.

AU - Compta, Y.

AU - Revesz, T.

AU - Lees, A.

AU - Cairns, N.

AU - Halliday, G.M.

AU - Mann, D.

AU - Pickering-Brown, S.

AU - Dickson, D.W.

AU - Singleton, A.

AU - Hardy, J.

PY - 2014

Y1 - 2014

U2 - https://doi.org/10.1093/hmg/ddu334

DO - https://doi.org/10.1093/hmg/ddu334

M3 - Article

C2 - 24973356

SN - 0964-6906

VL - 23

SP - 6139

EP - 6146

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 23

ER -