@article{826c46bc655e4798a1eb30800b395bc9,
title = "Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults",
abstract = "Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.",
author = "{ENIGMA Consortium} and Edith Hofer and Roshchupkin, {Gennady V.} and Adams, {Hieab H.H.} and Knol, {Maria J.} and Honghuang Lin and Shuo Li and Habil Zare and Shahzad Ahmad and Armstrong, {Nicola J.} and Satizabal, {Claudia L.} and Manon Bernard and Bis, {Joshua C.} and Gillespie, {Nathan A.} and Michelle Luciano and Aniket Mishra and Markus Scholz and Alexander Teumer and Rui Xia and Xueqiu Jian and Mosley, {Thomas H.} and Yasaman Saba and Lukas Pirpamer and Stephan Seiler and Becker, {James T.} and Owen Carmichael and Rotter, {Jerome I.} and Psaty, {Bruce M.} and Lopez, {Oscar L.} and Najaf Amin and {van der Lee}, {Sven J.} and Qiong Yang and Himali, {Jayandra J.} and Pauline Maillard and Beiser, {Alexa S.} and Charles DeCarli and Sherif Karama and Lewis, {Lindsay B.} and Mat Harris and Neale, {Michael C.} and Brouwer, {Rachel M.} and {den Braber}, Anouk and Fedko, {Iryna O.} and Heslenfeld, {Dirk J.} and Hottenga, {Jouke Jan} and Yuri Milaneschi and Boomsma, {Dorret I.} and {de Geus}, {Eco J.C.} and Jaap Oosterlaan and Polderman, {Tinca J.C.} and Danielle Posthuma and Bastin, {Mark E.} and Deary, {Ian J.} and {Veronica Witte}, A. and Jansen, {Iris E.} and Lianne Schmaal and Veltman, {Dick J.} and Penninx, {Brenda W. J. H.} and Frauke Beyer and Markus Loeffler and Mather, {Karen A.} and Schofield, {Peter R.} and Anbupalam Thalamuthu and Kwok, {John B.}",
year = "2020",
month = dec,
day = "1",
doi = "https://doi.org/10.1038/s41467-020-18367-y",
language = "English",
volume = "11",
pages = "1--16",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}
