TY - JOUR
T1 - Genetic polymorphisms: importance for response to HMG-CoA reductase inhibitors
AU - Maitland-van der Zee, Anke Hilse
AU - Klungel, Olaf H.
AU - Stricker, Bruno H. Ch
AU - Verschuren, W. M. Monique
AU - Kastelein, John J. P.
AU - Leufkens, Hubertus G. M.
AU - de Boer, Anthonius
PY - 2002
Y1 - 2002
N2 - Coronary artery disease is among the leading causes of death worldwide. Clinical trials show a protective effect of statins against the sequelae of coronary artery disease. The mean risk reductions for subjects using statins compared with placebo found in these trials is about 30%. These are average reductions for all patients included in the trials. Important factors in interpreting the variability in the outcome of drug therapy include the patient's health profile, prognosis, disease severity, quality of drug prescribing, compliance with prescribed pharmacotherapy and the genetic profile of the patient. This review aims to give an overview of the known polymorphisms (Cholesteryl Ester Transfer Protein polymorphism, Stromelysin-1 polymorphism, -455G/A and TaqI polymorphisms of the beta-fibrinogen gene, apoE4, Asp(9)Asn mutation in the lipoprotein lipase gene, the -514 CT polymorphism in the hepatic lipase gene and the ACE deletion type gene) that have an influence on the effects of statins in the general population. The expectation is that in the future a subject's genotype may determine whether he will be treated with statins or not. Determining the genotype will not deny therapy to a subject, but will help in deciding the therapy that will suit the patient best. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved
AB - Coronary artery disease is among the leading causes of death worldwide. Clinical trials show a protective effect of statins against the sequelae of coronary artery disease. The mean risk reductions for subjects using statins compared with placebo found in these trials is about 30%. These are average reductions for all patients included in the trials. Important factors in interpreting the variability in the outcome of drug therapy include the patient's health profile, prognosis, disease severity, quality of drug prescribing, compliance with prescribed pharmacotherapy and the genetic profile of the patient. This review aims to give an overview of the known polymorphisms (Cholesteryl Ester Transfer Protein polymorphism, Stromelysin-1 polymorphism, -455G/A and TaqI polymorphisms of the beta-fibrinogen gene, apoE4, Asp(9)Asn mutation in the lipoprotein lipase gene, the -514 CT polymorphism in the hepatic lipase gene and the ACE deletion type gene) that have an influence on the effects of statins in the general population. The expectation is that in the future a subject's genotype may determine whether he will be treated with statins or not. Determining the genotype will not deny therapy to a subject, but will help in deciding the therapy that will suit the patient best. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved
U2 - https://doi.org/10.1016/S0021-9150(01)00725-0
DO - https://doi.org/10.1016/S0021-9150(01)00725-0
M3 - Review article
C2 - 12052467
SN - 0021-9150
VL - 163
SP - 213
EP - 222
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -