Genetic regulators of large-scale transcriptional signatures in cancer

Adam S. Adler; Meihong Lin; Hugo Horlings; Dimitry S. A. Nuyten; Marc J. van de Vijver; Howard Y. Chang

doi:https://doi.org/10.1038/ng1752

Genetic regulators of large-scale transcriptional signatures in cancer

Adam S. Adler, Meihong Lin, Hugo Horlings, Dimitry S. A. Nuyten, Marc J. van de Vijver, Howard Y. Chang

Research output: Contribution to journal › Article › Academic › peer-review

189 Citations (Scopus)

Abstract

Gene expression signatures encompassing dozens to hundreds of genes have been associated with many important parameters of cancer, but mechanisms of their control are largely unknown. Here we present a method based on genetic linkage that can prospectively identify functional regulators driving large-scale transcriptional signatures in cancer. Using this method we show that the wound response signature, a poor-prognosis expression pattern of 512 genes in breast cancer, is induced by coordinate amplifications of MYC and CSN5 (also known as JAB1 or COPS5). This information enabled experimental recapitulation, functional assessment and mechanistic elucidation of the wound signature in breast epithelial cells

Original language	English
Pages (from-to)	421-430
Journal	Nature Genetics
Volume	38
Issue number	4
DOIs	https://doi.org/10.1038/ng1752
Publication status	Published - 2006

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https://doi.org/10.1038/ng1752

Cite this

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AU - Chang, Howard Y.

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