Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity

Stephanie D. Hoekstra; Sven Stringer; Vivi M. Heine; Danielle Posthuma

doi:https://doi.org/10.3389/fncel.2017.00164

Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity

Stephanie D. Hoekstra, Sven Stringer, Vivi M. Heine, Danielle Posthuma

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Abstract

Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.

Original language	English
Article number	164
Pages (from-to)	164
Journal	Frontiers in cellular neuroscience
Volume	11
DOIs	https://doi.org/10.3389/fncel.2017.00164
Publication status	Published - 13 Jun 2017

Keywords

Disease models
Genetics
IPSC
Journal Article
Psychiatric diseases
Schizophrenia
Statistical power
Stem cells
Variability

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KW - Variability

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Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity

Abstract

Keywords

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