TY - JOUR
T1 - Genetics of HDL-C: a causal link to atherosclerosis?
AU - van Capelleveen, Julian C.
AU - Bochem, Andrea E.
AU - Motazacker, M. Mahdi
AU - Hovingh, G. Kees
AU - Kastelein, John J. P.
PY - 2013
Y1 - 2013
N2 - Prospective epidemiological studies have consistently reported an inverse association between HDL cholesterol (HDL-C) levels and the risk of cardiovascular disease (CVD). However, large intervention trials on HDL-C-increasing drugs and recent Mendelian randomization studies have questioned a causal relationship between HDL-C and atherosclerosis. HDL-C levels have been shown to be highly heritable, and the combination of HDL-C-associated SNPs in recent large-scale genome-wide association studies (GWAS) only explains a small proportion of this heritability. As a large part of our current understanding of HDL metabolism comes from genetic studies, further insights in this research field may aid us in elucidating HDL functionality in relation to CVD risk. In this review we focus on the question of whether genetically defined HDL-C levels are associated with risk of atherosclerosis. We also discuss the latest insights for HDL-C-associated genes and recent GWAS data
AB - Prospective epidemiological studies have consistently reported an inverse association between HDL cholesterol (HDL-C) levels and the risk of cardiovascular disease (CVD). However, large intervention trials on HDL-C-increasing drugs and recent Mendelian randomization studies have questioned a causal relationship between HDL-C and atherosclerosis. HDL-C levels have been shown to be highly heritable, and the combination of HDL-C-associated SNPs in recent large-scale genome-wide association studies (GWAS) only explains a small proportion of this heritability. As a large part of our current understanding of HDL metabolism comes from genetic studies, further insights in this research field may aid us in elucidating HDL functionality in relation to CVD risk. In this review we focus on the question of whether genetically defined HDL-C levels are associated with risk of atherosclerosis. We also discuss the latest insights for HDL-C-associated genes and recent GWAS data
U2 - https://doi.org/10.1007/s11883-013-0326-8
DO - https://doi.org/10.1007/s11883-013-0326-8
M3 - Article
C2 - 23591671
SN - 1523-3804
VL - 15
SP - 326
JO - Current Atherosclerosis Reports
JF - Current Atherosclerosis Reports
IS - 6
ER -