Genome-wide association analysis identifies multiple loci related to resting heart rate

M. Eijgelsheim; C. Newton-Cheh; N. Sotoodehnia; P.I.W. Bakker; M. Müller; A.C. Morrison; A.V. Smith; A. Isaacs; S. Sanna; M. Dörr; P. Navarro; C. Fuchsberger; I.M. Nolte; E.J.C. de Geus; K. Estrada; S.J. Hwang; J.C. Bis; I.M. Rückert; A. Alonso; L.J. Launer; J.J. Hottenga; F. Rivadeneira; P.A. Noseworthy; T.A. Rice; S. Perz; D.E. Arking; T.D. Spector; J.A. Kors; Y.S. Aulchenko; K.V. Tarasov; G. Homuth; S.H. Wild; F. Marroni; C. Gieger; C.M.M. Licht; R.J. Prineas; A. Hofman; J.I. Rotter; A.A. Hicks; F. Ernst; S.S. Najjar; A.F. Wright; A. Peters; E.R. Fox; B.A. Oostra; H.K. Kroemer; D. Couper; H. Völzke; H. Campbell; T. Meitinger; M. Uda; J.C.M. Witteman; B.M. Psaty; H.-E. Wichmann; T.B. Harris; S. Kääb; D.S. Siscovick; Y. Jamshidi; A.G. Uitterlinden; A.R. Folsom; M.G. Larson; J.F. Wilson; B.W.J.H. Penninx; H. Snieder; P.P. Pramstaller; C.M. van Duijn; E.G. Lakatta; S.B. Felix; V. Gudnason; A. Pfeufer; S.R. Heckbert; B.H.C. Stricker; E. Boerwinkle; C.J. O'Donnell

doi:https://doi.org/10.1093/hmg/ddq303

Genome-wide association analysis identifies multiple loci related to resting heart rate

M. Eijgelsheim, C. Newton-Cheh, N. Sotoodehnia, P.I.W. Bakker, M. Müller, A.C. Morrison, A.V. Smith, A. Isaacs, S. Sanna, M. Dörr, P. Navarro, C. Fuchsberger, I.M. Nolte, E.J.C. de Geus, K. Estrada, S.J. Hwang, J.C. Bis, I.M. Rückert, A. Alonso, L.J. LaunerJ.J. Hottenga, F. Rivadeneira, P.A. Noseworthy, T.A. Rice, S. Perz, D.E. Arking, T.D. Spector, J.A. Kors, Y.S. Aulchenko, K.V. Tarasov, G. Homuth, S.H. Wild, F. Marroni, C. Gieger, C.M.M. Licht, R.J. Prineas, A. Hofman, J.I. Rotter, A.A. Hicks, F. Ernst, S.S. Najjar, A.F. Wright, A. Peters, E.R. Fox, B.A. Oostra, H.K. Kroemer, D. Couper, H. Völzke, H. Campbell, T. Meitinger, M. Uda, J.C.M. Witteman, B.M. Psaty, H.-E. Wichmann, T.B. Harris, S. Kääb, D.S. Siscovick, Y. Jamshidi, A.G. Uitterlinden, A.R. Folsom, M.G. Larson, J.F. Wilson, B.W.J.H. Penninx, H. Snieder, P.P. Pramstaller, C.M. van Duijn, E.G. Lakatta, S.B. Felix, V. Gudnason, A. Pfeufer, S.R. Heckbert, B.H.C. Stricker, E. Boerwinkle, C.J. O'Donnell

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence pathologic heart rate states, modulate heart rate through cardiac structure and function or by improving our understanding of the physiology of heart rate regulation. To identify common genetic variants associated with heart rate, we performed a meta-analysis of 15 genome-wide association studies (GWAS), including 38 991 subjects of European ancestry, estimating the association between age-, sex-and body mass-adjusted RR interval (inverse heart rate) and ~2.5 million markers. Results with P < 5 × 10

Original language	English
Pages (from-to)	3885-3894
Journal	Human Molecular Genetics
Volume	19
Issue number	19
DOIs	https://doi.org/10.1093/hmg/ddq303
Publication status	Published - 2010

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Cite this

Eijgelsheim, M., Newton-Cheh, C., Sotoodehnia, N., Bakker, P. I. W., Müller, M., Morrison, A. C., Smith, A. V., Isaacs, A., Sanna, S., Dörr, M., Navarro, P., Fuchsberger, C., Nolte, I. M., de Geus, E. J. C., Estrada, K., Hwang, S. J., Bis, J. C., Rückert, I. M., Alonso, A., ... O'Donnell, C. J. (2010). Genome-wide association analysis identifies multiple loci related to resting heart rate. Human Molecular Genetics, 19(19), 3885-3894. https://doi.org/10.1093/hmg/ddq303

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abstract = "Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence pathologic heart rate states, modulate heart rate through cardiac structure and function or by improving our understanding of the physiology of heart rate regulation. To identify common genetic variants associated with heart rate, we performed a meta-analysis of 15 genome-wide association studies (GWAS), including 38 991 subjects of European ancestry, estimating the association between age-, sex-and body mass-adjusted RR interval (inverse heart rate) and ~2.5 million markers. Results with P < 5 × 10",

author = "M. Eijgelsheim and C. Newton-Cheh and N. Sotoodehnia and P.I.W. Bakker and M. M{\"u}ller and A.C. Morrison and A.V. Smith and A. Isaacs and S. Sanna and M. D{\"o}rr and P. Navarro and C. Fuchsberger and I.M. Nolte and {de Geus}, E.J.C. and K. Estrada and S.J. Hwang and J.C. Bis and I.M. R{\"u}ckert and A. Alonso and L.J. Launer and J.J. Hottenga and F. Rivadeneira and P.A. Noseworthy and T.A. Rice and S. Perz and D.E. Arking and T.D. Spector and J.A. Kors and Y.S. Aulchenko and K.V. Tarasov and G. Homuth and S.H. Wild and F. Marroni and C. Gieger and C.M.M. Licht and R.J. Prineas and A. Hofman and J.I. Rotter and A.A. Hicks and F. Ernst and S.S. Najjar and A.F. Wright and A. Peters and E.R. Fox and B.A. Oostra and H.K. Kroemer and D. Couper and H. V{\"o}lzke and H. Campbell and T. Meitinger and M. Uda and J.C.M. Witteman and B.M. Psaty and H.-E. Wichmann and T.B. Harris and S. K{\"a}{\"a}b and D.S. Siscovick and Y. Jamshidi and A.G. Uitterlinden and A.R. Folsom and M.G. Larson and J.F. Wilson and B.W.J.H. Penninx and H. Snieder and P.P. Pramstaller and {van Duijn}, C.M. and E.G. Lakatta and S.B. Felix and V. Gudnason and A. Pfeufer and S.R. Heckbert and B.H.C. Stricker and E. Boerwinkle and C.J. O'Donnell",

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doi = "https://doi.org/10.1093/hmg/ddq303",

language = "English",

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pages = "3885--3894",

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Eijgelsheim, M, Newton-Cheh, C, Sotoodehnia, N, Bakker, PIW, Müller, M, Morrison, AC, Smith, AV, Isaacs, A, Sanna, S, Dörr, M, Navarro, P, Fuchsberger, C, Nolte, IM, de Geus, EJC, Estrada, K, Hwang, SJ, Bis, JC, Rückert, IM, Alonso, A, Launer, LJ, Hottenga, JJ, Rivadeneira, F, Noseworthy, PA, Rice, TA, Perz, S, Arking, DE, Spector, TD, Kors, JA, Aulchenko, YS, Tarasov, KV, Homuth, G, Wild, SH, Marroni, F, Gieger, C, Licht, CMM, Prineas, RJ, Hofman, A, Rotter, JI, Hicks, AA, Ernst, F, Najjar, SS, Wright, AF, Peters, A, Fox, ER, Oostra, BA, Kroemer, HK, Couper, D, Völzke, H, Campbell, H, Meitinger, T, Uda, M, Witteman, JCM, Psaty, BM, Wichmann, H-E, Harris, TB, Kääb, S, Siscovick, DS, Jamshidi, Y, Uitterlinden, AG, Folsom, AR, Larson, MG, Wilson, JF, Penninx, BWJH, Snieder, H, Pramstaller, PP, van Duijn, CM, Lakatta, EG, Felix, SB, Gudnason, V, Pfeufer, A, Heckbert, SR, Stricker, BHC, Boerwinkle, E & O'Donnell, CJ 2010, 'Genome-wide association analysis identifies multiple loci related to resting heart rate', Human Molecular Genetics, vol. 19, no. 19, pp. 3885-3894. https://doi.org/10.1093/hmg/ddq303

TY - JOUR

T1 - Genome-wide association analysis identifies multiple loci related to resting heart rate

AU - Eijgelsheim, M.

AU - Newton-Cheh, C.

AU - Sotoodehnia, N.

AU - Bakker, P.I.W.

AU - Müller, M.

AU - Morrison, A.C.

AU - Smith, A.V.

AU - Isaacs, A.

AU - Sanna, S.

AU - Dörr, M.

AU - Navarro, P.

AU - Fuchsberger, C.

AU - Nolte, I.M.

AU - de Geus, E.J.C.

AU - Estrada, K.

AU - Hwang, S.J.

AU - Bis, J.C.

AU - Rückert, I.M.

AU - Alonso, A.

AU - Launer, L.J.

AU - Hottenga, J.J.

AU - Rivadeneira, F.

AU - Noseworthy, P.A.

AU - Rice, T.A.

AU - Perz, S.

AU - Arking, D.E.

AU - Spector, T.D.

AU - Kors, J.A.

AU - Aulchenko, Y.S.

AU - Tarasov, K.V.

AU - Homuth, G.

AU - Wild, S.H.

AU - Marroni, F.

AU - Gieger, C.

AU - Licht, C.M.M.

AU - Prineas, R.J.

AU - Hofman, A.

AU - Rotter, J.I.

AU - Hicks, A.A.

AU - Ernst, F.

AU - Najjar, S.S.

AU - Wright, A.F.

AU - Peters, A.

AU - Fox, E.R.

AU - Oostra, B.A.

AU - Kroemer, H.K.

AU - Couper, D.

AU - Völzke, H.

AU - Campbell, H.

AU - Meitinger, T.

AU - Uda, M.

AU - Witteman, J.C.M.

AU - Psaty, B.M.

AU - Wichmann, H.-E.

AU - Harris, T.B.

AU - Kääb, S.

AU - Siscovick, D.S.

AU - Jamshidi, Y.

AU - Uitterlinden, A.G.

AU - Folsom, A.R.

AU - Larson, M.G.

AU - Wilson, J.F.

AU - Penninx, B.W.J.H.

AU - Snieder, H.

AU - Pramstaller, P.P.

AU - van Duijn, C.M.

AU - Lakatta, E.G.

AU - Felix, S.B.

AU - Gudnason, V.

AU - Pfeufer, A.

AU - Heckbert, S.R.

AU - Stricker, B.H.C.

AU - Boerwinkle, E.

AU - O'Donnell, C.J.

PY - 2010

Y1 - 2010

N2 - Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence pathologic heart rate states, modulate heart rate through cardiac structure and function or by improving our understanding of the physiology of heart rate regulation. To identify common genetic variants associated with heart rate, we performed a meta-analysis of 15 genome-wide association studies (GWAS), including 38 991 subjects of European ancestry, estimating the association between age-, sex-and body mass-adjusted RR interval (inverse heart rate) and ~2.5 million markers. Results with P < 5 × 10

AB - Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence pathologic heart rate states, modulate heart rate through cardiac structure and function or by improving our understanding of the physiology of heart rate regulation. To identify common genetic variants associated with heart rate, we performed a meta-analysis of 15 genome-wide association studies (GWAS), including 38 991 subjects of European ancestry, estimating the association between age-, sex-and body mass-adjusted RR interval (inverse heart rate) and ~2.5 million markers. Results with P < 5 × 10

U2 - https://doi.org/10.1093/hmg/ddq303

DO - https://doi.org/10.1093/hmg/ddq303

M3 - Article

C2 - 20639392

SN - 0964-6906

VL - 19

SP - 3885

EP - 3894

JO - Human molecular genetics

JF - Human molecular genetics

IS - 19

ER -