Genome-wide association study of obsessive-compulsive disorder

S.E. Stewart, D. Yu, J.M. Scharf, B.M. Neale, J.A. Fagerness, C.A. Mathews, P.D. Arnold, P.D. Evans, E.R. Gamazon, L.K. Davis, L. Osiecki, L. McGrath, S. Haddad, J. Crane, D. Hezel, C. Illmann, C. Mayerfeld, A.I. Konkashbaev, C. Liu, A. PluzhnikovA. Tikhomirov, C.K. Edlund, S.L. Rauch, R. Moessner, P. Falkai, W. Maier, S. Ruhrmann, H.J. Grabe, L. Lennertz, M. Wagner, L. Bellodi, M.C. Cavallini, M.A. Richter, E.H. Cook, J.L. Kennedy, D. Rosenberg, D.J. Stein, S.M. Hemmings, C. Lochner, A. Azzam, D.A. Chavira, E. Fournier, H. Garrido, B. Sheppard, P. Umaña, D.L. Murphy, J.R. Wendland, J. Veenstra-Vanderweele, D. Denys, R. Blom, D. Deforce, F. van Nieuwerburgh, H.G. Westenberg, S. Walitza, K. Egberts, T. Renner, E.C. Miguel, C. Cappi, A.G. Hounie, M. Conceição do Rosário, A.S. Sampaio, H. Vallada, H. Nicolini, N. Lanzagorta, B. Camarena, R. Delorme, M. Leboyer, C.N. Pato, M.T. Pato, E. Voyiaziakis, P. Heutink, D.C. Cath, D. Posthuma, J.H. Smit, J. Samuels, O.J. Bienvenu, B. Cullen, A.J. Fyer, M.A. Grados, B.D. Greenberg, J.T. McCracken, M.A. Riddle, Y. Wang, V. Coric, J.F. Leckman, M. Bloch, C. Pittenger, V. Eapen, D.W. Black, R.A. Ophoff, E. Strengman, D. Cusi, M. Turiel, F. Frau, F. Macciardi, J.R. Gibbs, M.R. Cookson, A. Singleton, J. Hardy, A.T. Crenshaw, M.A. Parkin, D.B. Mirel, D.V. Conti, S. Purcell, G. Nestadt, G.L. Hanna, M.A. Jenike, J.A. Knowles, N. Cox, D.L. Pauls, C. Illman, S. Arepalli, A. Dillman, L. Ferrucci, D. G. Hernandez, R. Johnson, D. L. Longo, M. A. Nalls, R. O Brien, B. Traynor, J. Troncoso, M. van der Brug, H. R. Zielke, A. Zonderman, M. Ryten, C. Smith, D. Trabzuni, R. Walker, Mike Weale

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Abstract

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469 410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case-control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case-control analysis, the lowest two P-values were located within DLGAP1 (P=2.49 × 10
Original languageEnglish
Pages (from-to)788-798
JournalMolecular psychiatry
Volume18
Issue number7
Early online date14 Aug 2012
DOIs
Publication statusPublished - 2013

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