TY - JOUR
T1 - Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
AU - Neurology Working Group of the CHARGE Consortium
AU - Lahti, Jari
AU - Tuominen, Samuli
AU - Yang, Qiong
AU - Pergola, Giulio
AU - Ahmad, Shahzad
AU - Amin, Najaf
AU - Armstrong, Nicola J.
AU - Beiser, Alexa
AU - Bey, Katharina
AU - Bis, Joshua C.
AU - Boerwinkle, Eric
AU - Bressler, Jan
AU - Campbell, Archie
AU - Campbell, Harry
AU - Chen, Qiang
AU - Corley, Janie
AU - Cox, Simon R.
AU - Davies, Gail
AU - De Jager, Philip L.
AU - Derks, Eske M.
AU - Faul, Jessica D.
AU - Fitzpatrick, Annette L.
AU - Fohner, Alison E.
AU - Ford, Ian
AU - Fornage, Myriam
AU - Gerring, Zachary
AU - Grabe, Hans J.
AU - Grodstein, Francine
AU - Gudnason, Vilmundur
AU - Simonsick, Eleanor
AU - Holliday, Elizabeth G.
AU - Joshi, Peter K.
AU - Kajantie, Eero
AU - Kaprio, Jaakko
AU - Karell, Pauliina
AU - Kleineidam, Luca
AU - Knol, Maria J.
AU - Kochan, Nicole A.
AU - Kwok, John B.
AU - Leber, Markus
AU - Lam, Max
AU - Lee, Teresa
AU - Li, Shuo
AU - Loukola, Anu
AU - Luck, Tobias
AU - Marioni, Riccardo E.
AU - Mather, Karen A.
AU - Medland, Sarah
AU - Mirza, Saira S.
AU - van der Lee, Sven J.
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022/11
Y1 - 2022/11
N2 - Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
AB - Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
UR - http://www.scopus.com/inward/record.url?scp=85136173551&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41380-022-01710-8
DO - https://doi.org/10.1038/s41380-022-01710-8
M3 - Article
C2 - 35974141
SN - 1359-4184
VL - 27
SP - 4419
EP - 4431
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 11
ER -