Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients

Pauline Depuydt; Valentina Boeva; Toby D. Hocking; Robrecht Cannoodt; Inge M. Ambros; Peter F. Ambros; Shahab Asgharzadeh; Edward F. Attiyeh; Valérie Combaret; Raffaella Defferrari; Matthias Fischer; Barbara Hero; Michael D. Hogarty; Meredith S. Irwin; Jan Koster; Susan Kreissman; Ruth Ladenstein; Eve Lapouble; Geneviève Laureys; Wendy B. London; Katia Mazzocco; Akira Nakagawara; Rosa Noguera; Miki Ohira; Julie R. Park; Ulrike Pötschger; Jessica Theissen; Gian Paolo Tonini; Dominique Valteau-Couanet; Luigi Varesio; Rogier Versteeg; Frank Speleman; John M. Maris; Gudrun Schleiermacher; Katleen de Preter

doi:https://doi.org/10.1093/jnci/djy022

Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients

Pauline Depuydt, Valentina Boeva, Toby D. Hocking, Robrecht Cannoodt, Inge M. Ambros, Peter F. Ambros, Shahab Asgharzadeh, Edward F. Attiyeh, Valérie Combaret, Raffaella Defferrari, Matthias Fischer, Barbara Hero, Michael D. Hogarty, Meredith S. Irwin, Jan Koster, Susan Kreissman, Ruth Ladenstein, Eve Lapouble, Geneviève Laureys, Wendy B. LondonKatia Mazzocco, Akira Nakagawara, Rosa Noguera, Miki Ohira, Julie R. Park, Ulrike Pötschger, Jessica Theissen, Gian Paolo Tonini, Dominique Valteau-Couanet, Luigi Varesio, Rogier Versteeg, Frank Speleman, John M. Maris, Gudrun Schleiermacher, Katleen de Preter

Research output: Contribution to journal › Article › Academic › peer-review

72 Citations (Scopus)

Abstract

Background: Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are still disappointingly low. Somatic chromosomal copy number aberrations have been shown to be associated with patient outcome, particularly in low- and intermediate-risk neuroblastoma patients. To improve outcome prediction in high-risk neuroblastoma, we aimed to design a prognostic classification method based on copy number aberrations.

Original language	English
Pages (from-to)	1084-1093
Journal	Journal of the National Cancer Institute
Volume	110
Issue number	10
DOIs	https://doi.org/10.1093/jnci/djy022
Publication status	Published - 2018

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Depuydt, P., Boeva, V., Hocking, T. D., Cannoodt, R., Ambros, I. M., Ambros, P. F., Asgharzadeh, S., Attiyeh, E. F., Combaret, V., Defferrari, R., Fischer, M., Hero, B., Hogarty, M. D., Irwin, M. S., Koster, J., Kreissman, S., Ladenstein, R., Lapouble, E., Laureys, G., ... de Preter, K. (2018). Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients. Journal of the National Cancer Institute, 110(10), 1084-1093. https://doi.org/10.1093/jnci/djy022

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title = "Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients",

abstract = "Background: Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are still disappointingly low. Somatic chromosomal copy number aberrations have been shown to be associated with patient outcome, particularly in low- and intermediate-risk neuroblastoma patients. To improve outcome prediction in high-risk neuroblastoma, we aimed to design a prognostic classification method based on copy number aberrations.",

author = "Pauline Depuydt and Valentina Boeva and Hocking, {Toby D.} and Robrecht Cannoodt and Ambros, {Inge M.} and Ambros, {Peter F.} and Shahab Asgharzadeh and Attiyeh, {Edward F.} and Val{\'e}rie Combaret and Raffaella Defferrari and Matthias Fischer and Barbara Hero and Hogarty, {Michael D.} and Irwin, {Meredith S.} and Jan Koster and Susan Kreissman and Ruth Ladenstein and Eve Lapouble and Genevi{\`e}ve Laureys and London, {Wendy B.} and Katia Mazzocco and Akira Nakagawara and Rosa Noguera and Miki Ohira and Park, {Julie R.} and Ulrike P{\"o}tschger and Jessica Theissen and Tonini, {Gian Paolo} and Dominique Valteau-Couanet and Luigi Varesio and Rogier Versteeg and Frank Speleman and Maris, {John M.} and Gudrun Schleiermacher and {de Preter}, Katleen",

year = "2018",

doi = "https://doi.org/10.1093/jnci/djy022",

language = "English",

volume = "110",

pages = "1084--1093",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

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Depuydt, P, Boeva, V, Hocking, TD, Cannoodt, R, Ambros, IM, Ambros, PF, Asgharzadeh, S, Attiyeh, EF, Combaret, V, Defferrari, R, Fischer, M, Hero, B, Hogarty, MD, Irwin, MS, Koster, J, Kreissman, S, Ladenstein, R, Lapouble, E, Laureys, G, London, WB, Mazzocco, K, Nakagawara, A, Noguera, R, Ohira, M, Park, JR, Pötschger, U, Theissen, J, Tonini, GP, Valteau-Couanet, D, Varesio, L, Versteeg, R, Speleman, F, Maris, JM, Schleiermacher, G & de Preter, K 2018, 'Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients', Journal of the National Cancer Institute, vol. 110, no. 10, pp. 1084-1093. https://doi.org/10.1093/jnci/djy022

TY - JOUR

T1 - Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients

AU - Depuydt, Pauline

AU - Boeva, Valentina

AU - Hocking, Toby D.

AU - Cannoodt, Robrecht

AU - Ambros, Inge M.

AU - Ambros, Peter F.

AU - Asgharzadeh, Shahab

AU - Attiyeh, Edward F.

AU - Combaret, Valérie

AU - Defferrari, Raffaella

AU - Fischer, Matthias

AU - Hero, Barbara

AU - Hogarty, Michael D.

AU - Irwin, Meredith S.

AU - Koster, Jan

AU - Kreissman, Susan

AU - Ladenstein, Ruth

AU - Lapouble, Eve

AU - Laureys, Geneviève

AU - London, Wendy B.

AU - Mazzocco, Katia

AU - Nakagawara, Akira

AU - Noguera, Rosa

AU - Ohira, Miki

AU - Park, Julie R.

AU - Pötschger, Ulrike

AU - Theissen, Jessica

AU - Tonini, Gian Paolo

AU - Valteau-Couanet, Dominique

AU - Varesio, Luigi

AU - Versteeg, Rogier

AU - Speleman, Frank

AU - Maris, John M.

AU - Schleiermacher, Gudrun

AU - de Preter, Katleen

PY - 2018

Y1 - 2018

N2 - Background: Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are still disappointingly low. Somatic chromosomal copy number aberrations have been shown to be associated with patient outcome, particularly in low- and intermediate-risk neuroblastoma patients. To improve outcome prediction in high-risk neuroblastoma, we aimed to design a prognostic classification method based on copy number aberrations.

AB - Background: Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are still disappointingly low. Somatic chromosomal copy number aberrations have been shown to be associated with patient outcome, particularly in low- and intermediate-risk neuroblastoma patients. To improve outcome prediction in high-risk neuroblastoma, we aimed to design a prognostic classification method based on copy number aberrations.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053371565&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/29514301

U2 - https://doi.org/10.1093/jnci/djy022

DO - https://doi.org/10.1093/jnci/djy022

M3 - Article

C2 - 29514301

SN - 0027-8874

VL - 110

SP - 1084

EP - 1093

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 10

ER -

Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients

Abstract

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