Glioblastomas are by far the most frequent and the most malignant tumors originating in the parenchyma of the central nervous system (CNS). In the revised 4th edition of the WHO classification of CNS tumors (published in 2016), classification of these gliomas has fundamentally changed as for the first time presence or absence of particular molecular aberrations is now part of their definition. This review discusses current insights in characteristics of the main molecular subgroups of glioblastoma and how the paradigm shift of a purely histologic towards a histomolecular classification of gliomas has impacted the clinical diagnosis of these tumors.

Original languageEnglish
Title of host publicationEncyclopedia of Cancer
Number of pages14
ISBN (Electronic)9780128124857
Publication statusPublished - 1 Jan 2018


  • EGFR amplification
  • Glioblastoma
  • Glioma
  • H3 k27m mutation
  • Histopathology
  • IDH1/IDH2 mutation
  • Molecular diagnostics
  • TERT promoter mutation
  • WHO classification

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