Global multi-center and multi-modal magnetic resonance imaging study of obsessive-compulsive disorder: Harmonization and monitoring of protocols in healthy volunteers and phantoms

Petra J. W. Pouwels, Chris Vriend, Feng Liu, Niels T. de Joode, Maria C. G. Otaduy, Bruno Pastorello, Frances C. Robertson, Ganesan Venkatasubramanian, Jonathan Ipser, Seonjoo Lee, Marcelo C. Batistuzzo, Marcelo Q. Hoexter, Christine Lochner, Euripedes C. Miguel, Janardhanan C. Narayanaswamy, Rashmi Rao, Y. C. Janardhan Reddy, Roseli G. Shavitt, Karthik Sheshachala, Dan J. SteinAnton J. L. M. van Balkom, Melanie Wall, Helen Blair Simpson, Odile A. van den Heuvel

Research output: Contribution to journalArticleAcademicpeer-review


Objectives: We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations. Methods: We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans. Results: Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites. Conclusions: Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory.
Original languageEnglish
Pages (from-to)e1931
JournalInternational journal of methods in psychiatric research
Early online date15 Aug 2022
Publication statusE-pub ahead of print - 15 Aug 2022


  • DWI
  • fMRI
  • image quality measure
  • multi-vendor
  • structural MRI

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