TY - JOUR
T1 - Global multi-center and multi-modal magnetic resonance imaging study of obsessive-compulsive disorder
T2 - Harmonization and monitoring of protocols in healthy volunteers and phantoms
AU - Pouwels, Petra J. W.
AU - Vriend, Chris
AU - Liu, Feng
AU - de Joode, Niels T.
AU - Otaduy, Maria C. G.
AU - Pastorello, Bruno
AU - Robertson, Frances C.
AU - Venkatasubramanian, Ganesan
AU - Ipser, Jonathan
AU - Lee, Seonjoo
AU - Batistuzzo, Marcelo C.
AU - Hoexter, Marcelo Q.
AU - Lochner, Christine
AU - Miguel, Euripedes C.
AU - Narayanaswamy, Janardhanan C.
AU - Rao, Rashmi
AU - Janardhan Reddy, Y. C.
AU - Shavitt, Roseli G.
AU - Sheshachala, Karthik
AU - Stein, Dan J.
AU - van Balkom, Anton J. L. M.
AU - Wall, Melanie
AU - Simpson, Helen Blair
AU - van den Heuvel, Odile A.
N1 - Funding Information: In addition to NIMH funding, we acknowledge the infrastructural and imaging support provided by the New York State‐Office of Mental Health at the New York site and the “Accelerator Program for Discovery in Brain disorders using Stem Cells (ADBS)" funded by the Department of Biotechnology, Government of India. Ganesan Venkatasubramanian acknowledges the support of Department of Biotechnology (DBT) ‐ Wellcome Trust India Alliance (IA/CRC/19/1/610005) and Department of Biotechnology, Government of India (BT/HRD‐NBA‐NWB/38/2019‐20 (6)). Publisher Copyright: © 2022 The Authors. International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd.
PY - 2022/8/15
Y1 - 2022/8/15
N2 - Objectives: We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations. Methods: We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans. Results: Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites. Conclusions: Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory.
AB - Objectives: We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations. Methods: We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans. Results: Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites. Conclusions: Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory.
KW - DWI
KW - fMRI
KW - image quality measure
KW - multi-vendor
KW - structural MRI
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135914518&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35971639
U2 - https://doi.org/10.1002/mpr.1931
DO - https://doi.org/10.1002/mpr.1931
M3 - Article
C2 - 35971639
SN - 1049-8931
SP - e1931
JO - International Journal of Methods in Psychiatric Research
JF - International Journal of Methods in Psychiatric Research
ER -