TY - JOUR
T1 - Global Type-Specific Genital Human Papillomavirus Prevalence in Men, by Sexual Orientation
T2 - A Systematic Review and Meta-Analysis
AU - Kusters, Johannes M A
AU - Brouwer, Jesca G M
AU - van Benthem, Birgit H B
AU - Heijne, Janneke C M
AU - Schim van der Loeff, Maarten F
N1 - Funding Information: Financial support. This work was supported by the Ministry of Public Health, Welfare and Sport, the Netherlands. Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023/10/15
Y1 - 2023/10/15
N2 - BACKGROUND: Knowledge on genital type-specific human papillomavirus (HPV) prevalence among men is important for prevention of HPV-related cancers and other diseases. Men who have sex with men (MSM) have higher anal prevalence than men who have sex with women only (MSW) but for genital HPV this is unclear. We performed a systematic review and meta-analysis of type-specific genital HPV prevalence among men, by sexual orientation.METHODS: MEDLINE and Embase were used for searching publications reporting on male genital HPV prevalence with data from November 2011 onwards. A random-effects meta-analysis was conducted estimating pooled type-specific and grouped external genital and urethral HPV prevalence. Subgroup analyses were conducted for sexual orientation.RESULTS: Twenty-nine studies were eligible. Of those, 13 studies reported prevalence among MSM, 5 among MSW, and 13 studies did not stratify by sexual orientation. The most common genotypes were HPV-6 and HPV-16 for both anatomical locations, although heterogeneity was high. HPV prevalence was similar among studies reporting on MSW, MSM, and men with unknown sexual orientation.CONCLUSIONS: Genital HPV is common among men, with HPV-6 and HPV-16 being the most common genotypes. Type-specific HPV genital prevalence appears to be similar among MSM and MSW, which contrasts with earlier findings on anal HPV.
AB - BACKGROUND: Knowledge on genital type-specific human papillomavirus (HPV) prevalence among men is important for prevention of HPV-related cancers and other diseases. Men who have sex with men (MSM) have higher anal prevalence than men who have sex with women only (MSW) but for genital HPV this is unclear. We performed a systematic review and meta-analysis of type-specific genital HPV prevalence among men, by sexual orientation.METHODS: MEDLINE and Embase were used for searching publications reporting on male genital HPV prevalence with data from November 2011 onwards. A random-effects meta-analysis was conducted estimating pooled type-specific and grouped external genital and urethral HPV prevalence. Subgroup analyses were conducted for sexual orientation.RESULTS: Twenty-nine studies were eligible. Of those, 13 studies reported prevalence among MSM, 5 among MSW, and 13 studies did not stratify by sexual orientation. The most common genotypes were HPV-6 and HPV-16 for both anatomical locations, although heterogeneity was high. HPV prevalence was similar among studies reporting on MSW, MSM, and men with unknown sexual orientation.CONCLUSIONS: Genital HPV is common among men, with HPV-6 and HPV-16 being the most common genotypes. Type-specific HPV genital prevalence appears to be similar among MSM and MSW, which contrasts with earlier findings on anal HPV.
KW - Female
KW - HIV Infections/epidemiology
KW - Homosexuality, Male
KW - Human Papillomavirus Viruses
KW - Human papillomavirus 16
KW - Humans
KW - Male
KW - Papillomaviridae/genetics
KW - Papillomavirus Infections/epidemiology
KW - Prevalence
KW - Risk Factors
KW - Sexual Behavior
KW - Sexual and Gender Minorities
KW - Sexually Transmitted Diseases
UR - http://www.scopus.com/inward/record.url?scp=85159583784&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiad109
DO - 10.1093/infdis/jiad109
M3 - Article
C2 - 37079383
SN - 0022-1899
VL - 228
SP - 1023
EP - 1032
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
IS - 8
ER -