Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

Daniël H van Raalte, C Bruce Verchere

Research output: Contribution to journalShort survey*Academicpeer-review


Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.

Original languageEnglish
Pages (from-to)442-5
Number of pages4
JournalTrends in Endocrinology and Metabolism
Issue number7
Publication statusPublished - Jul 2016


  • Journal Article

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