TY - JOUR
T1 - Glucose production in response to glucagon is comparable in preterm AGA and SGA infants
AU - van Kempen, Anne A. M. W.
AU - Ackermans, Mariëtte T.
AU - Endert, Erik
AU - Kok, Johanna H.
AU - Sauerwein, Hans P.
PY - 2005
Y1 - 2005
N2 - Background & Aims: Low plasma glucose concentrations are more often detected in small-for-gestational-age (SGA) than in appropriate-for-gestational-age (AGA) infants. This is ascribed to impaired glucose production due to presumed tower liver glycogen stores in SGA infants. The change in glucose production induced by glucagon is considered to be an indicator of Liver glycogen content. We compared the effect of glucagon on glucose kinetics in preterm AGA and SGA infants. Methods: In 5 AGA and 5 SGA preterm infants (postnatal age: 3-6 days) glucose production and gluconeogenesis were measured using stable isotopes immediately before and for 1 h after a bolus of glucagon. Results: After glucagon the plasma glucose concentration and glucose production increased significantly over time (P <0.05 and P <0.0001, respectively). The changes were comparable between AGA and SGA infants. Glycogenolysis contributed 75-80% to the increase in glucose production. Conclusion: The increase in glucose production after glucagon was similar in preterm AGA and SGA infants, and mainly due to an increase in glycogenolysis. Based on the assumption that glycogenolysis is an indicator of liver glycogen content, our data do not support the hypothesis that liver glycogen content is tower in preterm SGA compared to AGA infants after the first postnatal day. (c) 2005 Elsevier Ltd. ALL rights reserved
AB - Background & Aims: Low plasma glucose concentrations are more often detected in small-for-gestational-age (SGA) than in appropriate-for-gestational-age (AGA) infants. This is ascribed to impaired glucose production due to presumed tower liver glycogen stores in SGA infants. The change in glucose production induced by glucagon is considered to be an indicator of Liver glycogen content. We compared the effect of glucagon on glucose kinetics in preterm AGA and SGA infants. Methods: In 5 AGA and 5 SGA preterm infants (postnatal age: 3-6 days) glucose production and gluconeogenesis were measured using stable isotopes immediately before and for 1 h after a bolus of glucagon. Results: After glucagon the plasma glucose concentration and glucose production increased significantly over time (P <0.05 and P <0.0001, respectively). The changes were comparable between AGA and SGA infants. Glycogenolysis contributed 75-80% to the increase in glucose production. Conclusion: The increase in glucose production after glucagon was similar in preterm AGA and SGA infants, and mainly due to an increase in glycogenolysis. Based on the assumption that glycogenolysis is an indicator of liver glycogen content, our data do not support the hypothesis that liver glycogen content is tower in preterm SGA compared to AGA infants after the first postnatal day. (c) 2005 Elsevier Ltd. ALL rights reserved
U2 - https://doi.org/10.1016/j.clnu.2005.02.004
DO - https://doi.org/10.1016/j.clnu.2005.02.004
M3 - Article
C2 - 16182036
SN - 0261-5614
VL - 24
SP - 727
EP - 736
JO - Clinical nutrition (Edinburgh, Scotland)
JF - Clinical nutrition (Edinburgh, Scotland)
IS - 5
ER -