Glutamate changes in healthy young adulthood

Anouk Marsman; René C.W. Mandl; Martijn P. van den Heuvel; Vincent O. Boer; Jannie P. Wijnen; Dennis W.J. Klomp; Peter R. Luijten; Hulshoff Pol Hilleke E.

doi:https://doi.org/10.1016/j.euroneuro.2012.11.003

Glutamate changes in healthy young adulthood

Anouk Marsman, René C.W. Mandl, Martijn P. van den Heuvel, Vincent O. Boer, Jannie P. Wijnen, Dennis W.J. Klomp, Peter R. Luijten, Hulshoff Pol Hilleke E.

Human Genetics (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Scopus)

Abstract

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and has been associated with several cognitive functions that are known to change with age. In rodents and humans age-related glutamate changes have been found in several brain areas. In this cross-sectional study the presence and extent of age-associated glutamate changes in the medial frontal cortex of healthy young adults were measured. Proton magnetic resonance spectroscopy (¹H-MRS) and brain imaging were performed at 7T in a 2×2×2cm³ voxel in 33 participants between 18 and 31 years old. Glutamate concentrations and grey and white matter volume could be successfully determined at an ultra-high magnetic field strength. Glutamate concentrations were lower in older individuals (0.33mM/year). This decline is in line with grey matter thinning in the medial frontal cortex, but could not be explained by cortical thinning alone. Therefore, the decrease in glutamate in young adulthood may be due to physiological changes rather than anatomical changes.

Original language	English
Pages (from-to)	1484-1490
Number of pages	7
Journal	European neuropsychopharmacology
Volume	23
Issue number	11
DOIs	https://doi.org/10.1016/j.euroneuro.2012.11.003
Publication status	Published - 1 Nov 2013

Keywords

Aging
Glutamate
Magnetic resonance spectroscopy

Access to Document

https://doi.org/10.1016/j.euroneuro.2012.11.003

Cite this

@article{9bc2e12ca4e04bbd9f34f56362fe0ba5,

title = "Glutamate changes in healthy young adulthood",

abstract = "Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and has been associated with several cognitive functions that are known to change with age. In rodents and humans age-related glutamate changes have been found in several brain areas. In this cross-sectional study the presence and extent of age-associated glutamate changes in the medial frontal cortex of healthy young adults were measured. Proton magnetic resonance spectroscopy (1H-MRS) and brain imaging were performed at 7T in a 2×2×2cm3 voxel in 33 participants between 18 and 31 years old. Glutamate concentrations and grey and white matter volume could be successfully determined at an ultra-high magnetic field strength. Glutamate concentrations were lower in older individuals (0.33mM/year). This decline is in line with grey matter thinning in the medial frontal cortex, but could not be explained by cortical thinning alone. Therefore, the decrease in glutamate in young adulthood may be due to physiological changes rather than anatomical changes.",

keywords = "Aging, Glutamate, Magnetic resonance spectroscopy",

author = "Anouk Marsman and Mandl, {Ren{\'e} C.W.} and {van den Heuvel}, {Martijn P.} and Boer, {Vincent O.} and Wijnen, {Jannie P.} and Klomp, {Dennis W.J.} and Luijten, {Peter R.} and {Hilleke E.}, {Hulshoff Pol}",

year = "2013",

month = nov,

day = "1",

doi = "https://doi.org/10.1016/j.euroneuro.2012.11.003",

language = "English",

volume = "23",

pages = "1484--1490",

journal = "European Neuropsychopharmacology",

issn = "1873-7862",

publisher = "Elsevier",

number = "11",

}

TY - JOUR

T1 - Glutamate changes in healthy young adulthood

AU - Marsman, Anouk

AU - Mandl, René C.W.

AU - van den Heuvel, Martijn P.

AU - Boer, Vincent O.

AU - Wijnen, Jannie P.

AU - Klomp, Dennis W.J.

AU - Luijten, Peter R.

AU - Hilleke E., Hulshoff Pol

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and has been associated with several cognitive functions that are known to change with age. In rodents and humans age-related glutamate changes have been found in several brain areas. In this cross-sectional study the presence and extent of age-associated glutamate changes in the medial frontal cortex of healthy young adults were measured. Proton magnetic resonance spectroscopy (1H-MRS) and brain imaging were performed at 7T in a 2×2×2cm3 voxel in 33 participants between 18 and 31 years old. Glutamate concentrations and grey and white matter volume could be successfully determined at an ultra-high magnetic field strength. Glutamate concentrations were lower in older individuals (0.33mM/year). This decline is in line with grey matter thinning in the medial frontal cortex, but could not be explained by cortical thinning alone. Therefore, the decrease in glutamate in young adulthood may be due to physiological changes rather than anatomical changes.

AB - Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and has been associated with several cognitive functions that are known to change with age. In rodents and humans age-related glutamate changes have been found in several brain areas. In this cross-sectional study the presence and extent of age-associated glutamate changes in the medial frontal cortex of healthy young adults were measured. Proton magnetic resonance spectroscopy (1H-MRS) and brain imaging were performed at 7T in a 2×2×2cm3 voxel in 33 participants between 18 and 31 years old. Glutamate concentrations and grey and white matter volume could be successfully determined at an ultra-high magnetic field strength. Glutamate concentrations were lower in older individuals (0.33mM/year). This decline is in line with grey matter thinning in the medial frontal cortex, but could not be explained by cortical thinning alone. Therefore, the decrease in glutamate in young adulthood may be due to physiological changes rather than anatomical changes.

KW - Aging

KW - Glutamate

KW - Magnetic resonance spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84886779860&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.euroneuro.2012.11.003

DO - https://doi.org/10.1016/j.euroneuro.2012.11.003

M3 - Article

C2 - 23245833

SN - 1873-7862

VL - 23

SP - 1484

EP - 1490

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 11

ER -

Glutamate changes in healthy young adulthood

Abstract

Keywords

Access to Document

Other files and links

Cite this