TY - JOUR
T1 - Going Micro in Leptospirosis Kidney Disease
AU - Chancharoenthana, Wiwat
AU - Leelahavanichkul, Asada
AU - Schultz, Marcus J.
AU - Dondorp, Arjen M.
N1 - Funding Information: Funding: This work was funded by Mahidol University–Basic Research Fund: fiscal year 2021 (FRB640032) (Contract No. BRF1-A42/2564) and Basic Research Fund: fiscal year 2022 (FRB650007/0185) (Contract No. BRF1-062/2565), and Health System Research Institute (HRSI)– Flagship Project Fund: fiscal year 2020 (W.C.). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected infectious disease caused by Leptospira spp., as well as a reemerging disease and global public health problem with respect to morbidity and mortality both in humans and animals. Leptospirosis emerges as a leading cause of acute febrile illness along with hepatorenal injury in many countries, including Thailand. While most affected persons are symptomatic in acute disease, which is always difficult to differentiate from other tropical diseases, there is growing evidence of subtle manifestations that cause unrecognized chronic symptoms. The kidney is one of the common organs affected by Leptospires. Although acute kidney injury in the spectrum of interstitial nephritis is a well-described characteristic in severe leptospirosis, chronic kidney disease from leptospirosis is widely discussed. Early recognition of severe leptospirosis leads to reduce morbidity and mortality. Thus, in this review, we highlight the spectrum of characteristics involved in leptospirosis kidney disease and the use of serologic and molecular methods, as well as the treatments of severe leptospirosis.
AB - Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected infectious disease caused by Leptospira spp., as well as a reemerging disease and global public health problem with respect to morbidity and mortality both in humans and animals. Leptospirosis emerges as a leading cause of acute febrile illness along with hepatorenal injury in many countries, including Thailand. While most affected persons are symptomatic in acute disease, which is always difficult to differentiate from other tropical diseases, there is growing evidence of subtle manifestations that cause unrecognized chronic symptoms. The kidney is one of the common organs affected by Leptospires. Although acute kidney injury in the spectrum of interstitial nephritis is a well-described characteristic in severe leptospirosis, chronic kidney disease from leptospirosis is widely discussed. Early recognition of severe leptospirosis leads to reduce morbidity and mortality. Thus, in this review, we highlight the spectrum of characteristics involved in leptospirosis kidney disease and the use of serologic and molecular methods, as well as the treatments of severe leptospirosis.
KW - Acute kidney injury
KW - Immune response
KW - Interstitial nephritis
KW - Leptospirosis
UR - http://www.scopus.com/inward/record.url?scp=85124604695&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/cells11040698
DO - https://doi.org/10.3390/cells11040698
M3 - Review article
C2 - 35203344
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 4
M1 - 698
ER -