Granulosa cell tumors of the ovary: The clinical value of serum inhibin A and B levels in a large single center cohort

C. H. Mom, M. J.A. Engelen, P. H.B. Willemse, J. A. Gietema, K. A. ten Hoor, E. G.E. de Vries, A. G.J. van der Zee

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives.: In patients with a granulosa cell tumor of the ovary, the value of serum inhibin A and B concentrations for the assessment of disease status was investigated. Methods.: In 30 consecutive patients with a stage I-III granulosa cell tumor, inhibin A and B concentrations were measured in pre- and post-treatment serum samples. Clinical data concerning diagnosis, treatment and follow-up of these patients were related to serum inhibin A and B concentrations. Serum samples from 41 premenopausal females with cervical dysplasia served as controls. Results.: In 30 patients, 13 (43%) recurrences were observed during a median follow-up of 10 years (range 1-31 years). Serum inhibin A and B concentrations were elevated in respectively 67% and 89% of the patients at diagnosis, and in 58% and 85% at recurrence. Inhibin A and B concentrations were normal in all controls. Sensitivity of inhibin A testing for the diagnosis of granulosa cell tumor was 67% with a specificity of 100%, compared to 89% and 100% respectively for inhibin B (ns). Elevations in serum inhibin B concentrations predated recurrences by a median of 11 months. None of the patients in remission showed increased concentrations of inhibin A and B. Conclusion.: Inhibin B seems to be the predominant form of inhibin secreted by granulosa cell tumors and appears to reflect disease status more accurately than inhibin A. Measurement of serum inhibin B concentrations may be preferred for the follow-up of granulosa cell tumors.

Original languageEnglish
Pages (from-to)365-372
Number of pages8
JournalGynecologic oncology
Volume105
Issue number2
DOIs
Publication statusPublished - 1 May 2007

Keywords

  • Granulosa cell tumor
  • Inhibin A
  • Inhibin B
  • Sex-cord stromal tumor
  • Tumor marker

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