TY - JOUR
T1 - Gray matter atrophy in dementia with Lewy bodies with and without concomitant Alzheimer's disease pathology
AU - van der Zande, Jessica J.
AU - Steenwijk, Martijn D.
AU - ten Kate, Mara
AU - Wattjes, Mike P.
AU - Scheltens, Philip
AU - Lemstra, Afina W.
PY - 2018
Y1 - 2018
N2 - We aimed to study if patients with dementia with Lewy bodies (DLB) who have concomitant Alzheimer's disease (AD) pathology (detected antemortem by cerebrospinal fluid [CSF] biomarkers) have additional loss of gray matter volume. Ninety-eight DLB patients were divided into a “pure DLB” (DLB/AD− n = 62) and a “mixed DLB” group (DLB/AD+, n = 36) and matched for age and symptom duration to 84 AD patients and 75 controls. We compared visual atrophy ratings, and in a subset, we analyzed cortical thickness and subcortical gray matter volumes. DLB/AD+ patients had more pronounced medial temporal lobe atrophy (MTA) compared to DLB/AD− (mean [total] MTA score 2.5 vs. 1.3, p = 0.02). Global and parietal atrophy scores were comparable between the 3 dementia groups and differed from controls. MTA score was associated with CSF Aβ-42, while posterior cortical and global atrophy scores were associated with CSF tau. Cortical thinning was found in DLB/AD− DLB/AD+, and AD compared to controls. Concomitant AD pathology seems to cause additional (hippocampal) atrophy in DLB, and this may contribute to a more devastating disease course in DLB/AD+ patients.
AB - We aimed to study if patients with dementia with Lewy bodies (DLB) who have concomitant Alzheimer's disease (AD) pathology (detected antemortem by cerebrospinal fluid [CSF] biomarkers) have additional loss of gray matter volume. Ninety-eight DLB patients were divided into a “pure DLB” (DLB/AD− n = 62) and a “mixed DLB” group (DLB/AD+, n = 36) and matched for age and symptom duration to 84 AD patients and 75 controls. We compared visual atrophy ratings, and in a subset, we analyzed cortical thickness and subcortical gray matter volumes. DLB/AD+ patients had more pronounced medial temporal lobe atrophy (MTA) compared to DLB/AD− (mean [total] MTA score 2.5 vs. 1.3, p = 0.02). Global and parietal atrophy scores were comparable between the 3 dementia groups and differed from controls. MTA score was associated with CSF Aβ-42, while posterior cortical and global atrophy scores were associated with CSF tau. Cortical thinning was found in DLB/AD− DLB/AD+, and AD compared to controls. Concomitant AD pathology seems to cause additional (hippocampal) atrophy in DLB, and this may contribute to a more devastating disease course in DLB/AD+ patients.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052055906&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30149288
U2 - https://doi.org/10.1016/j.neurobiolaging.2018.07.005
DO - https://doi.org/10.1016/j.neurobiolaging.2018.07.005
M3 - Article
C2 - 30149288
SN - 0197-4580
VL - 71
SP - 171
EP - 178
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -