TY - JOUR
T1 - Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives
AU - Groen, Robin N.
AU - de Clercq, Nicolien C.
AU - Nieuwdorp, Max
AU - Hoenders, H. J. Rogier
AU - Groen, Albert K.
PY - 2018
Y1 - 2018
N2 - Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders.
AB - Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046547543&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29673295
U2 - https://doi.org/10.1080/10408363.2018.1463507
DO - https://doi.org/10.1080/10408363.2018.1463507
M3 - Review article
C2 - 29673295
SN - 1040-8363
VL - 55
SP - 283
EP - 293
JO - Critical Reviews in Clinical Laboratory Sciences
JF - Critical Reviews in Clinical Laboratory Sciences
IS - 4
ER -