TY - JOUR
T1 - Handgrip Strength Cannot Be Assumed a Proxy for Overall Muscle Strength
AU - Yeung, Suey S. Y.
AU - Reijnierse, Esmee M.
AU - Trappenburg, Marijke C.
AU - Hogrel, Jean-Yves
AU - McPhee, Jamie S.
AU - Piasecki, Mathew
AU - Sipila, Sarianna
AU - Salpakoski, Anu
AU - Butler-Browne, Gillian
AU - Pääsuke, Mati
AU - Gapeyeva, Helena
AU - Narici, Marco V.
AU - Meskers, Carel G. M.
AU - Maier, Andrea B.
PY - 2018/8
Y1 - 2018/8
N2 - Objectives: Dynapenia, low muscle strength, is predictive for negative health outcomes and is usually expressed as handgrip strength (HGS). Whether HGS can be a proxy for overall muscle strength and whether this depends on age and health status is controversial. This study assessed the agreement between HGS and knee extension strength (KES) in populations differing in age and health status. Design: Data were retrieved from 5 cohorts. Setting and Participants: Community, geriatric outpatient clinics, and a hospital. Five cohorts (960 individuals, 49.8% male) encompassing healthy young and older individuals, geriatric outpatients, and older individuals post hip fracture were included. Measures: HGS and KES were measured according to the protocol of each cohort. Pearson correlation was performed to analyze the association between HGS and KES, stratified by sex. HGS and KES were standardized into sex-specific z scores. The agreement between standardized HGS and standardized KES at population level and individual level were assessed by intraclass correlation coefficients (ICC) and Bland-Altman analysis. Results: Pearson correlation coefficients were low in healthy young (male: 0.36 to 0.45, female: 0.45) and healthy older individuals (male: 0.35 to 0.37, female: 0.44), and moderate in geriatric outpatients (male and female: 0.54) and older individuals post hip fracture (male: 0.44, female: 0.57) (P <.05, except for male older individuals post hip fracture [P =.07]). Intraclass correlation coefficient values were poor to moderate in all populations (ie, healthy young individuals [0.41, 0.45], healthy older individuals [0.37, 0.41, 0.44], geriatric outpatients [0.54], and older individuals post hip fracture [0.54]). Bland-Altman analysis showed that within the same population of age and health status, agreement between HGS and KES varied on individual level. Conclusions: At both population and individual level, HGS and KES showed a low to moderate agreement independently of age and health status. HGS alone should not be assumed a proxy for overall muscle strength.
AB - Objectives: Dynapenia, low muscle strength, is predictive for negative health outcomes and is usually expressed as handgrip strength (HGS). Whether HGS can be a proxy for overall muscle strength and whether this depends on age and health status is controversial. This study assessed the agreement between HGS and knee extension strength (KES) in populations differing in age and health status. Design: Data were retrieved from 5 cohorts. Setting and Participants: Community, geriatric outpatient clinics, and a hospital. Five cohorts (960 individuals, 49.8% male) encompassing healthy young and older individuals, geriatric outpatients, and older individuals post hip fracture were included. Measures: HGS and KES were measured according to the protocol of each cohort. Pearson correlation was performed to analyze the association between HGS and KES, stratified by sex. HGS and KES were standardized into sex-specific z scores. The agreement between standardized HGS and standardized KES at population level and individual level were assessed by intraclass correlation coefficients (ICC) and Bland-Altman analysis. Results: Pearson correlation coefficients were low in healthy young (male: 0.36 to 0.45, female: 0.45) and healthy older individuals (male: 0.35 to 0.37, female: 0.44), and moderate in geriatric outpatients (male and female: 0.54) and older individuals post hip fracture (male: 0.44, female: 0.57) (P <.05, except for male older individuals post hip fracture [P =.07]). Intraclass correlation coefficient values were poor to moderate in all populations (ie, healthy young individuals [0.41, 0.45], healthy older individuals [0.37, 0.41, 0.44], geriatric outpatients [0.54], and older individuals post hip fracture [0.54]). Bland-Altman analysis showed that within the same population of age and health status, agreement between HGS and KES varied on individual level. Conclusions: At both population and individual level, HGS and KES showed a low to moderate agreement independently of age and health status. HGS alone should not be assumed a proxy for overall muscle strength.
KW - Muscle strength
KW - aged
KW - geriatric assessment
KW - knee extension strength
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048760531&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29935982
UR - http://www.scopus.com/inward/record.url?scp=85048760531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048760531&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jamda.2018.04.019
DO - https://doi.org/10.1016/j.jamda.2018.04.019
M3 - Article
C2 - 29935982
SN - 1525-8610
VL - 19
SP - 703
EP - 709
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
IS - 8
ER -
