TY - JOUR
T1 - Heart Failure and Pancreas Exocrine Insufficiency
T2 - Pathophysiological Mechanisms and Clinical Point of View
AU - Dams, Olivier C.
AU - Vijver, Marlene A. T.
AU - van Veldhuisen, Charlotte L.
AU - Verdonk, Robert C.
AU - Besselink, Marc G.
AU - van Veldhuisen, Dirk J.
N1 - Publisher Copyright: © 2022 by the authors.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Heart failure is associated with decreased tissue perfusion and increased venous congestion that may result in organ dysfunction. This dysfunction has been investigated extensively for many organs, but data regarding pancreatic (exocrine) dysfunction are scarce. In the present review we will discuss the available data on the mechanisms of pancreatic damage, how heart failure can lead to exocrine dysfunction, and its clinical consequences. We will show that heart failure causes significant impairment of pancreatic exocrine function, particularly in the elderly, which may exacerbate the clinical syndrome of heart failure. In addition, pancreatic exocrine insufficiency may lead to further deterioration of cardiovascular disease and heart failure, thus constituting a true vicious circle. We aim to provide insight into the pathophysiological mechanisms that constitute this reciprocal relation. Finally, novel treatment options for pancreatic dysfunction in heart failure are discussed.
AB - Heart failure is associated with decreased tissue perfusion and increased venous congestion that may result in organ dysfunction. This dysfunction has been investigated extensively for many organs, but data regarding pancreatic (exocrine) dysfunction are scarce. In the present review we will discuss the available data on the mechanisms of pancreatic damage, how heart failure can lead to exocrine dysfunction, and its clinical consequences. We will show that heart failure causes significant impairment of pancreatic exocrine function, particularly in the elderly, which may exacerbate the clinical syndrome of heart failure. In addition, pancreatic exocrine insufficiency may lead to further deterioration of cardiovascular disease and heart failure, thus constituting a true vicious circle. We aim to provide insight into the pathophysiological mechanisms that constitute this reciprocal relation. Finally, novel treatment options for pancreatic dysfunction in heart failure are discussed.
KW - cardiac cachexia
KW - congestion
KW - heart failure
KW - interactions
KW - malnutrition
KW - pancreatic exocrine insufficiency
UR - http://www.scopus.com/inward/record.url?scp=85136373803&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/jcm11144128
DO - https://doi.org/10.3390/jcm11144128
M3 - Review article
C2 - 35887892
SN - 2077-0383
VL - 11
JO - Journal of clinical medicine
JF - Journal of clinical medicine
IS - 14
M1 - 4128
ER -