Hematologic Malignancies in Pregnancy: Management Guidelines From an International Consensus Meeting

Michael Lishner, Irit Avivi, Jane F. Apperley, Daan Dierickx, Andrew M. Evens, Monica Fumagalli, Irena Nulman, Fuat S. Oduncu, Fedro Alessandro Peccatori, Susan Robinson, Kristel van Calsteren, Tineke Vandenbroucke, Frank van den Heuvel, Frederic Amant

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose The incidence of hematologic malignancies during pregnancy is 0.02%. However, this figure is increasing, as women delay conception until a later age. Systemic symptoms attributed to the development of a hematologic cancer may overlap with physiologic changes of pregnancy. A favorable prognosis is contingent upon early diagnosis and treatment. Therefore, a high index of suspicion is required by health care providers. Although timely, accurate diagnosis followed by appropriate staging is essential and should not be delayed due to pregnancy, management guidelines are lacking due to insufficient evidence-based research. Consequently, treatment is delayed, posing significant risks to maternal and fetal health, and potential pregnancy termination. This report provides guidelines for clinical management of hematologic cancers during the perinatal period, which were developed by a multidisciplinary team including an experienced hematologist/oncologist, a high-risk obstetrics specialist, a neonatologist, and experienced nurses, social workers, and psychologists. Methods These guidelines were developed by experts in the field during the first International Consensus Meeting of Prenatal Hematologic Malignancies, which took place in Leuven, Belgium, on May 23, 2014. Results and Conclusion This consensus summary equips health care professionals with novel diagnostic and treatment methodologies that aim for optimal treatment of the mother, while protecting fetal and pediatric health. (C) 2015 by American Society of Clinical Oncology
Original languageEnglish
Pages (from-to)501-+
JournalJournal of clinical oncology
Volume34
Issue number5
DOIs
Publication statusPublished - 2016

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