TY - JOUR
T1 - Hematologic Malignancies in Pregnancy: Management Guidelines From an International Consensus Meeting
AU - Lishner, Michael
AU - Avivi, Irit
AU - Apperley, Jane F.
AU - Dierickx, Daan
AU - Evens, Andrew M.
AU - Fumagalli, Monica
AU - Nulman, Irena
AU - Oduncu, Fuat S.
AU - Peccatori, Fedro Alessandro
AU - Robinson, Susan
AU - van Calsteren, Kristel
AU - Vandenbroucke, Tineke
AU - van den Heuvel, Frank
AU - Amant, Frederic
PY - 2016
Y1 - 2016
N2 - Purpose The incidence of hematologic malignancies during pregnancy is 0.02%. However, this figure is increasing, as women delay conception until a later age. Systemic symptoms attributed to the development of a hematologic cancer may overlap with physiologic changes of pregnancy. A favorable prognosis is contingent upon early diagnosis and treatment. Therefore, a high index of suspicion is required by health care providers. Although timely, accurate diagnosis followed by appropriate staging is essential and should not be delayed due to pregnancy, management guidelines are lacking due to insufficient evidence-based research. Consequently, treatment is delayed, posing significant risks to maternal and fetal health, and potential pregnancy termination. This report provides guidelines for clinical management of hematologic cancers during the perinatal period, which were developed by a multidisciplinary team including an experienced hematologist/oncologist, a high-risk obstetrics specialist, a neonatologist, and experienced nurses, social workers, and psychologists. Methods These guidelines were developed by experts in the field during the first International Consensus Meeting of Prenatal Hematologic Malignancies, which took place in Leuven, Belgium, on May 23, 2014. Results and Conclusion This consensus summary equips health care professionals with novel diagnostic and treatment methodologies that aim for optimal treatment of the mother, while protecting fetal and pediatric health. (C) 2015 by American Society of Clinical Oncology
AB - Purpose The incidence of hematologic malignancies during pregnancy is 0.02%. However, this figure is increasing, as women delay conception until a later age. Systemic symptoms attributed to the development of a hematologic cancer may overlap with physiologic changes of pregnancy. A favorable prognosis is contingent upon early diagnosis and treatment. Therefore, a high index of suspicion is required by health care providers. Although timely, accurate diagnosis followed by appropriate staging is essential and should not be delayed due to pregnancy, management guidelines are lacking due to insufficient evidence-based research. Consequently, treatment is delayed, posing significant risks to maternal and fetal health, and potential pregnancy termination. This report provides guidelines for clinical management of hematologic cancers during the perinatal period, which were developed by a multidisciplinary team including an experienced hematologist/oncologist, a high-risk obstetrics specialist, a neonatologist, and experienced nurses, social workers, and psychologists. Methods These guidelines were developed by experts in the field during the first International Consensus Meeting of Prenatal Hematologic Malignancies, which took place in Leuven, Belgium, on May 23, 2014. Results and Conclusion This consensus summary equips health care professionals with novel diagnostic and treatment methodologies that aim for optimal treatment of the mother, while protecting fetal and pediatric health. (C) 2015 by American Society of Clinical Oncology
U2 - https://doi.org/10.1200/JCO.2015.62.4445
DO - https://doi.org/10.1200/JCO.2015.62.4445
M3 - Article
C2 - 26628463
SN - 0732-183X
VL - 34
SP - 501-+
JO - Journal of clinical oncology
JF - Journal of clinical oncology
IS - 5
ER -