Hemodynamic effects of epicardial stenoses.

Lorena Casadonte, Maria Siebes

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


This chapter starts by a brief review of coronary physiology in terms of pressure-flow relationships and effects of vessel distensibility on microvascular resistance to lay the foundation for interpretation of coronary stenosis hemodynamics. The fluid dynamics of stenosis pressure gradient, resistance, and its dependency on flow and stenosis dimensions is outlined in the next section. Special consideration is given to serial lesions, stenosis compliance, and diffuse coronary narrowing. The last section discusses the hemodynamic effect of coronary epicardial stenoses on coronary blood flow and the need for integration of multiple physiological parameters to arrive at a well-founded procedural decision for an individual patient suffering from ischemic heart disease.
Original languageEnglish
Title of host publicationPhysiological Assessment of Coronary Stenoses and the Microcirculation
EditorsJavier Escaned, Justin Davies
PublisherSpringer London
ISBN (Electronic)9781447152453
ISBN (Print)9781447152446
Publication statusPublished - 11 Aug 2017


  • Coronary artery disease
  • Hemodynamics
  • Ischemia
  • Physiological severity
  • Pressure drop-flow relationship
  • Stenosis

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