TY - JOUR
T1 - Hemodynamic Parameters in the Parent Arteries of Unruptured Intracranial Aneurysms Depend on Aneurysm Size and Are Different Compared to Contralateral Arteries
T2 - A 7 Tesla 4D Flow MRI Study
AU - van Tuijl, Rick J.
AU - Timmins, Kimberley M.
AU - Velthuis, Birgitta K.
AU - van Ooij, Pim
AU - Zwanenburg, Jaco J. M.
AU - Ruigrok, Ynte M.
AU - van der Schaaf, Irene C.
N1 - Publisher Copyright: © 2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
PY - 2024/1
Y1 - 2024/1
N2 - Background: Different Circle of Willis (CoW) variants have variable prevalences of aneurysm development, but the hemodynamic variation along the CoW and its relation to presence and size of unruptured intracranial aneurysms (UIAs) are not well known. Purpose: Gain insight into hemodynamic imaging markers of the CoW for UIA development by comparing these outcomes to the corresponding contralateral artery without an UIA using 4D flow magnetic resonance imaging (MRI). Study Type: Retrospective, cross-sectional study. Subjects: Thirty-eight patients with an UIA, whereby 27 were women and a mean age of 62 years old. Field Strength/Sequence: Four-dimensional phase-contrast (PC) MRI with a 3D time-resolved velocity encoded gradient echo sequence at 7 T. Assessment: Hemodynamic parameters (blood flow, velocity pulsatility index [vPI], mean velocity, distensibility, and wall shear stress [peak systolic (WSSMAX), and time-averaged (WSSMEAN)]) in the parent artery of the UIA were compared to the corresponding contralateral artery without an UIA and were related to UIA size. Statistical Tests: Paired t-tests and Pearson Correlation tests. The threshold for statistical significance was P < 0.05 (two-tailed). Results: Blood flow, mean velocity, WSSMAX, and WSSMEAN were significantly higher, while vPI was lower, in the parent artery relative to contralateral artery. The WSSMAX of the parent artery significantly increased linearly while the WSSMEAN decreased linearly with increasing UIA size. Conclusions: Hemodynamic parameters and WSS differ between parent vessels of UIAs and corresponding contralateral vessels. WSS correlates with UIA size, supporting a potential hemodynamic role in aneurysm pathology. Level of Evidence: 2. Technical Efficacy: Stage 2.
AB - Background: Different Circle of Willis (CoW) variants have variable prevalences of aneurysm development, but the hemodynamic variation along the CoW and its relation to presence and size of unruptured intracranial aneurysms (UIAs) are not well known. Purpose: Gain insight into hemodynamic imaging markers of the CoW for UIA development by comparing these outcomes to the corresponding contralateral artery without an UIA using 4D flow magnetic resonance imaging (MRI). Study Type: Retrospective, cross-sectional study. Subjects: Thirty-eight patients with an UIA, whereby 27 were women and a mean age of 62 years old. Field Strength/Sequence: Four-dimensional phase-contrast (PC) MRI with a 3D time-resolved velocity encoded gradient echo sequence at 7 T. Assessment: Hemodynamic parameters (blood flow, velocity pulsatility index [vPI], mean velocity, distensibility, and wall shear stress [peak systolic (WSSMAX), and time-averaged (WSSMEAN)]) in the parent artery of the UIA were compared to the corresponding contralateral artery without an UIA and were related to UIA size. Statistical Tests: Paired t-tests and Pearson Correlation tests. The threshold for statistical significance was P < 0.05 (two-tailed). Results: Blood flow, mean velocity, WSSMAX, and WSSMEAN were significantly higher, while vPI was lower, in the parent artery relative to contralateral artery. The WSSMAX of the parent artery significantly increased linearly while the WSSMEAN decreased linearly with increasing UIA size. Conclusions: Hemodynamic parameters and WSS differ between parent vessels of UIAs and corresponding contralateral vessels. WSS correlates with UIA size, supporting a potential hemodynamic role in aneurysm pathology. Level of Evidence: 2. Technical Efficacy: Stage 2.
KW - aneurysm pathology
KW - hemodynamics
KW - intracranial aneurysm
KW - ipsilateral versus contralateral
KW - wall shear stress
UR - http://www.scopus.com/inward/record.url?scp=85158082060&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/jmri.28756
DO - https://doi.org/10.1002/jmri.28756
M3 - Article
C2 - 37144669
SN - 1053-1807
VL - 59
SP - 223
EP - 230
JO - Journal of magnetic resonance imaging
JF - Journal of magnetic resonance imaging
IS - 1
ER -