Herpes viral proteins manipulating the peptide transporter TAP

E. Reits; A. Griekspoor; J. Neefjes

Herpes viral proteins manipulating the peptide transporter TAP

E. Reits, A. Griekspoor, J. Neefjes

Cell Biology and Histology (AMC)

Research output: Contribution to journal › Review article › Academic › peer-review

2 Citations (Scopus)

Abstract

The peptide transporter associated with antigen processing (TAP) is crucial for class I-restricted antigen presentation because it transfers cytosolic peptides into the endoplasmic reticulum (ER) lumen for class I binding. It is therefore not surprising that TAP is targeted for inactivation by many viruses. Herpesviruses have been very successful in designing various proteins that inactivate TAP. We summarise current knowledge on the class I antigen presentation pathway and the function, structure and action of TAP and its viral inhibitors

Original language	English
Pages (from-to)	75-83
Journal	Current topics in microbiology and immunology
Volume	269
Publication status	Published - 2002

Cite this

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title = "Herpes viral proteins manipulating the peptide transporter TAP",

abstract = "The peptide transporter associated with antigen processing (TAP) is crucial for class I-restricted antigen presentation because it transfers cytosolic peptides into the endoplasmic reticulum (ER) lumen for class I binding. It is therefore not surprising that TAP is targeted for inactivation by many viruses. Herpesviruses have been very successful in designing various proteins that inactivate TAP. We summarise current knowledge on the class I antigen presentation pathway and the function, structure and action of TAP and its viral inhibitors",

author = "E. Reits and A. Griekspoor and J. Neefjes",

year = "2002",

language = "English",

volume = "269",

pages = "75--83",

journal = "Current topics in microbiology and immunology",

issn = "0070-217X",

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TY - JOUR

T1 - Herpes viral proteins manipulating the peptide transporter TAP

AU - Reits, E.

AU - Griekspoor, A.

AU - Neefjes, J.

PY - 2002

Y1 - 2002

N2 - The peptide transporter associated with antigen processing (TAP) is crucial for class I-restricted antigen presentation because it transfers cytosolic peptides into the endoplasmic reticulum (ER) lumen for class I binding. It is therefore not surprising that TAP is targeted for inactivation by many viruses. Herpesviruses have been very successful in designing various proteins that inactivate TAP. We summarise current knowledge on the class I antigen presentation pathway and the function, structure and action of TAP and its viral inhibitors

AB - The peptide transporter associated with antigen processing (TAP) is crucial for class I-restricted antigen presentation because it transfers cytosolic peptides into the endoplasmic reticulum (ER) lumen for class I binding. It is therefore not surprising that TAP is targeted for inactivation by many viruses. Herpesviruses have been very successful in designing various proteins that inactivate TAP. We summarise current knowledge on the class I antigen presentation pathway and the function, structure and action of TAP and its viral inhibitors

M3 - Review article

C2 - 12224517

SN - 0070-217X

VL - 269

SP - 75

EP - 83

JO - Current topics in microbiology and immunology

JF - Current topics in microbiology and immunology

ER -